1093134-70-3Relevant academic research and scientific papers
Discovery of novel hydroxamates as highly potent tumor necrosis factor-α converting enzyme inhibitors. Part II: Optimization of the S3′ pocket
Mazzola Jr., Robert D.,Zhu, Zhaoning,Sinning, Lisa,McKittrick, Brian,Lavey, Brian,Spitler, James,Kozlowski, Joseph,Neng-Yang, Shih,Zhou, Guowei,Guo, Zhuyan,Orth, Peter,Madison, Vincent,Sun, Jing,Lundell, Daniel,Niu, Xiaoda
scheme or table, p. 5809 - 5814 (2009/06/30)
A series of cyclopropyl hydroxamic acids were prepared. Many of the compounds displayed picomolar affinity for the TACE enzyme while maintaining good to excellent selectivity profiles versus MMP-1, -2, -3, -7, -14, and ADAM-10. X-ray analysis of an inhibi
