109317-07-9

Upstream product

• 58578-45-3 (2S)-2-(benzyloxycarbonylamino)-4-oxobutyric acid benzyl ester 
• 18598-63-5 L-cysteine methyl ester hydrochloride 
• 5714-80-7 D-cysteine methyl ester hydrochloride 
• 111197-44-5 (4S)-4-(Chloroformyl)methyl-3-[(phenylmethoxy)carbonyl]oxazolidin-5-one 
• 23632-66-8 (4S)-3-benzyloxycarbonyl-4-carboxymethyl-1,3-oxazolidin-5-one 
• 111197-45-6 (S)-4-(Formylmethyl)-5-oxooxazolidin-3-carbonsaeure-benzylester 
• 111197-46-7 (2R,5S,7S)-1-aza-7-benzyloxycarbonyl(hydroxymethyl)amino-8-oxo-4-thiabicyclo<3.3.0>octane-2-carboxylic acid methyl ester 
• 111197-46-7 (3S,6S)-6-(Benzyloxycarbonyl-hydroxymethyl-amino)-5-oxo-hexahydro-pyrrolo[2,1-b]thiazole-3-carboxylic acid methyl ester 

Downstream Products

• 1193377-35-3 (2R,5S,7S)-1-aza-7-benzyloxycarbonylamino-8-oxo-4-thiabicyclo[3.3.0]octane-2-carboxamide 
• 109429-19-8 (2R,3R,5S,7S)-1-aza-3-benzyloxy-7-benzyloxycarbonylamino-8-oxo-4-thiabicyclo<3.3.0>octane-2-carboxylic acid methyl ester 
• 109429-18-7 (2R,3S,5S,7S)-1-aza-3-benzyloxy-7-benzyloxycarbonylamino-8-oxo-4-thiabicyclo<3.3.0>octane-2-carboxylic acid methyl ester 
• 109317-13-7 (5R,7S)-1-aza-7-benzyloxycarbonylamino-8-oxo-4-thiabicyclo<3.3.0>oct-ene-carboxylic acid ethyl ester 
• 109429-20-1 (5S,7S)-1-aza-7-benzyloxycarbonylamino-8-oxo-4-thiabicyclo<3.3.0>oct-2-ene-2-carboxylic acid methyl ester 
• 109317-11-5 (5R,7S)-1-aza-7-benzyloxycarbonylamino-8-oxo-4-thiabicyclo<3.3.0>oct-2-ene-2-carboxylic acid methyl ester 
• 109317-12-6 Potassium; (6S,7aR)-6-benzyloxycarbonylamino-5-oxo-5,6,7,7a-tetrahydro-pyrrolo[2,1-b]thiazole-3-carboxylate 

Relevant academic research and scientific papers

A γ-LACTAM ANALOGUE OF THE PENEMS POSSESSING ANTIBACTERIAL ACTIVITY

The synthesis of a γ-lactam analogue of penems, from aspartic acid semi-aldehyde, which possessed antibacterial activity is described.

SYNTHESIS OF BICYCLIC γ-LACTAMS VIA OXAZOLIDINONES

Oxazolidinone aldehyde 10 reacts with L-cysteine methyl ester to produce N-hydroxymethyl bicyclic γ-lactam 11 in a double cyclisation reaction.With D-cysteine methyl ester, an epimeric mixture of N-hydroxymethyl bicyclic γ-lactams 12 is obtained.Bicyclic

A γ-Lactam Analogue of Penems Possessing Antibacterial Activity

The synthesis of a γ-lactam analogue of the penems, which showed antibacterial activity, is described.