109317-23-9 Usage
Uses
Used in Pharmaceutical Industry:
4-BROMO-2-METHYLPHENYLTHIOUREA is used as an antimicrobial agent for its antifungal and antibacterial activities, making it a promising candidate for the development of new antimicrobial drugs to combat resistant infections.
Used in Agrochemical Industry:
In the agrochemical sector, 4-BROMO-2-METHYLPHENYLTHIOUREA is utilized as a bioactive compound for its potential to control fungal and bacterial pathogens in crops, thereby enhancing agricultural productivity and crop protection.
Used in Materials Science:
4-BROMO-2-METHYLPHENYLTHIOUREA is employed in materials science for its potential applications in the development of new materials with antimicrobial properties, useful in various industrial and consumer products to prevent microbial growth and contamination.
Used in Medical Research:
4-BROMO-2-METHYLPHENYLTHIOUREA is used as a subject of research in the medical field for its potential therapeutic effects in treating various diseases and disorders, including cancer and diabetes. Further studies are necessary to explore its full potential and optimize its use in clinical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 109317-23-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,9,3,1 and 7 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 109317-23:
(8*1)+(7*0)+(6*9)+(5*3)+(4*1)+(3*7)+(2*2)+(1*3)=109
109 % 10 = 9
So 109317-23-9 is a valid CAS Registry Number.
InChI:InChI=1/C8H9BrN2S/c1-5-4-6(9)2-3-7(5)11-8(10)12/h2-4H,1H3,(H3,10,11,12)
109317-23-9Relevant academic research and scientific papers
Design, synthesis, X-ray crystallographic analysis, and biological evaluation of thiazole derivatives as potent and selective inhibitors of human dihydroorotate dehydrogenase
Zhu, Junsheng,Han, Le,Diao, Yanyan,Ren, Xiaoli,Xu, Minghao,Xu, Liuxin,Li, Shiliang,Li, Qiang,Dong, Dong,Huang, Jin,Liu, Xiaofeng,Zhao, Zhenjiang,Wang, Rui,Zhu, Lili,Xu, Yufang,Qian, Xuhong,Li, Honglin
, p. 1123 - 1139 (2015/03/04)
Human dihydroorotate dehydrogenase (HsDHODH) is a flavin-dependent mitochondrial enzyme that has been certified as a potential therapeutic target for the treatment of rheumatoid arthritis and other autoimmune diseases. On the basis of lead compound 4, which was previously identified as potential HsDHODH inhibitor, a novel series of thiazole derivatives were designed and synthesized. The X-ray complex structures of the promising analogues 12 and 33 confirmed that these inhibitors bind at the putative ubiquinone binding tunnel and guided us to explore more potent inhibitors, such as compounds 44, 46, and 47 which showed double digit nanomolar activities of 26, 18, and 29 nM, respectively. Moreover, 44 presented considerable anti-inflammation effect in vivo and significantly alleviated foot swelling in a dose-dependent manner, which disclosed that thiazole-scaffold analogues can be developed into the drug candidates for the treatment of rheumatoid arthritis by suppressing the bioactivity of HsDHODH.
