109317-32-0Relevant articles and documents
Condensed Tetrahydrobenzothiazoles: Part IV - Synthesis of Some 2-Substituted 4,5,6,7-Tetrahydrobenzothiazoles and Their 5,5 Dimethyl-7-oxo Derivatives
Udapudi, V. T.,Mahajanshetti, C. S.
, p. 1269 - 1272 (2007/10/02)
Condensation of 2-chlorocyclohexanone (I) with substituted thioamides (II) in hot ethanol affords 2-substituted 4,5,6,7-tetrahydrobenzothiazoles (III).A similar reaction of 2-bromodimedone (IV) with II does not give 2-substituted 5,5-dimethyl-7-oxo-4,5,6,7-tetrahydrobenzothiazoles alone (V); a gummy product containing more than two compounds (TLC) is obtained in each case.However, When the reaction is carried out in THF at room temperature for 36 hr, the expected hydrobromide salts (Va) are obtained in excellent yields.The free bases (V) are liberated from Va by treatment with Na2CO3 solution.Structures of III, Va and V have been established by elemental analyses and spectral data.They do not exhibit any significant antifungal or antibacterial activity in vitro.