1093191-20-8

Basic information

• Product Name: 4-[4-(2-(trimethylsilyl)ethynyl)benzyl]morpholine
• Synonyms: 4-[4-(2-(trimethylsilyl)ethynyl)benzyl]morpholine
• CAS NO: 1093191-20-8
• Molecular Weight: 273.45
• Mol File: 1093191-20-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-[4-(2-(trimethylsilyl)ethynyl)benzyl]morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-(2-(trimethylsilyl)ethynyl)benzyl]morpholine(1093191-20-8)
• EPA Substance Registry System: 4-[4-(2-(trimethylsilyl)ethynyl)benzyl]morpholine(1093191-20-8)

Safety Data

• Hazardous Substances Data: 1093191-20-8(Hazardous Substances Data)

Upstream product

• 589-15-1 1-bromomethyl-4-bromobenzene 
• 132833-51-3 4-[(4-bromophenyl)methyl]morpholine 
• 1066-54-2 trimethylsilylacetylene 

Downstream Products

• 933986-59-5 4-(morpholinomethyl)phenylacetylene 
• 1395409-50-3 methyl (2S,3R,4S,5S)-3,4-dihydroxy-5-(4-{2-[4-(morpholinomethyl)phenyl]ethynyl}phenyl)-2,3,4,5-tetrahydrofuran-2-carboxylate 
• 1395409-38-7 (2S,3R,4S,5S)-N,3,4-trihydroxy-5-(4-(2-(4-(morpholinomethyl)phenyl)ethynyl)phenyl)-tetrahydrofuran-2-carboxamide 
• 1093191-13-9 (S)-methyl 3-tert-butoxycarbonylamino-2-(7-((4-(morpholinomethyl)phenyl)ethynyl)-4-oxoquinazolin-3(4H)-yl)propanoate 
• 1093191-14-0 (S)-3-amino-N-hydroxy-2-(7-((4-(morpholinomethyl)phenyl)ethynyl)-4-oxoquinazolin-3(4H)-yl)propanamide 
• 1093189-50-4 C₂₃H₂₃NO₄ 
• 1093189-92-4 (E)-4-(4-(4-(morpholinomethyl)phenyl)but-1-en-3-ynyl)benzoic acid 
• 1093190-15-8 (E)-methyl 4-(4-(4-(morpholinomethyl)phenyl)but-1-en-3-ynyl)benzoate 

Relevant articles and documents

Design and stereoselective synthesis of a C-aryl furanoside as a conformationally constrained CHIR-090 analogue

The UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase (LpxC) is a promising target for the development of novel antibiotic substances against multidrug-resistant Gram-negative bacteria. The C-aryl glycoside 3 was designed as conformationally constrained analogue of the potent LpxC-inhibitor CHIR-090. The chiral pool synthesis of 3 started with d-mannose. The C-aryl glycoside 8 was synthesized stereoselectively by nucleophilic attack of 4-iodine-substituted phenyllithium and subsequent reduction with Et 3SiH. The ester 10 was obtained in a one-pot diol cleavage, CrO 3 oxidation, and esterification. A Sonogashira reaction of the aryl iodide 11 led to the alkyne 17 which was transformed with H2NOH into the hydroxamic acid 3.