1093254-98-8

Basic information

• Product Name: N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1-methyl-1H-imidazole-5-carboxamide
• Synonyms: N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1-methyl-1H-imidazole-5-carboxamide
• CAS NO: 1093254-98-8
• Molecular Weight: 419.242
• Mol File: 1093254-98-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1-methyl-1H-imidazole-5-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1-methyl-1H-imidazole-5-carboxamide(1093254-98-8)
• EPA Substance Registry System: N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1-methyl-1H-imidazole-5-carboxamide(1093254-98-8)

Safety Data

• Hazardous Substances Data: 1093254-98-8(Hazardous Substances Data)

Upstream product

• 1089178-83-5 3-{[3-(bromomethyl)-6-chloro-2-fluorophenyl]oxy}-5-chlorobenzonitrile 
• 1093260-77-5 3-[(6-amino-2-fluoro-3-methylphenyl)oxy]-5-chlorobenzonitrile 
• 1093260-75-3 3-chloro-5-[(2-fluoro-3-methyl-6-nitrophenyl)oxy]benzonitrile 
• 1093260-71-9 bis(1,1-dimethylethyl) {3-[(3-chloro-5-cyanophenyl)oxy]-2-fluoro-4-nitrophenyl}propanedioate 
• 770719-09-0 3-chloro-5-[(2,3-difluoro-6-nitrophenyl)oxy]benzonitrile 
• 41806-40-0 1-methyl-1H-imidazole-5-carboxylic acid 
• 1093254-29-5 3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-5-chlorobenzonitrile 

Downstream Products

• 1093254-99-9 N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1-methyl-1H-imidazole-5-carboxamide trifluoroacetate 

Relevant articles and documents

Rational design of potent non-nucleoside inhibitors of HIV-1 reverse transcriptase

A new series of non-nucleoside reverse transcriptase inhibitors based on an imidazole-amide biarylether scaffold has been identified and shown to possess potent antiviral activity against HIV-1, including the NNRTI-resistant Y188L mutated virus. X-ray crystallography of inhibitors bound to reverse transcriptase, including a structure of the Y188L RT protein, was used extensively to help identify and optimize the key hydrogen-bonding motif. This led directly to the design of compound 43 that exhibits remarkable antiviral activity (EC50 1 nM) against a wide range of NNRTI-resistant viruses and a favorable pharmacokinetic profile across multiple species.