1093386-73-2Relevant academic research and scientific papers
Radical addition to ynol ethers - A convenient procedure for the stereoselective preparation of α-iodo enol ethers in neutral conditions
Longpre, Fanny,Rusu, Natalia,Larouche, Maxime,Hanna, Rana,Daoust, Benoit
, p. 970 - 975 (2008/12/23)
α-Iodo enol ethers, precursors of acyl anion equivalents, are not easily prepared. Herein we report that addition of activated iodoalkanes to ynol ethers under mild and neutral radical reaction conditions leads to α-iodo enol ethers in moderate to excellent yields with high stereoselectivity. The reaction can be carried out in various solvents at different temperatures. The methodology allows the preparation of β-alkylated and β,β- dialkylated α-iodo enol ethers. Reduction of the carbon-iodine bond of these species leads to the corresponding enol ethers with good yields.
