1093407-74-9

Basic information

• Product Name: C₂₃H₂₆N₂O₆
• Synonyms: C₂₃H₂₆N₂O₆
• CAS NO: 1093407-74-9
• Molecular Weight: 426.469
• Mol File: 1093407-74-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₆N₂O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₆N₂O₆(1093407-74-9)
• EPA Substance Registry System: C₂₃H₂₆N₂O₆(1093407-74-9)

Safety Data

• Hazardous Substances Data: 1093407-74-9(Hazardous Substances Data)

Upstream product

• 74103-06-3 Ketorolac 
• 16115-68-7 diethyl L-aspartate hydrochloride 

Relevant articles and documents

Synthesis, characterization and pharmacological evaluation of amide prodrugs of ketorolac

Ketorolac (KC) suffers from the general side effects of NSAIDs, owing to presence of free carboxylic acid group. The study aimed to retard the adverse effects of gastrointestinal origin. Ten prodrugs of KC were synthesized by amidation with ethyl esters of amino acids, namely, glycine, l-phenylalanine, l-tryptophan, l-valine, l-isoleucine, l-alanine, l-leucine, l-glutamic acid, l-aspartic acid and β-alanine. Purified synthesized prodrugs were characterized by m.p., TLC, solubility, partition coefficients, elemental analyses, UV, FTIR, NMR and MS. Synthesized prodrugs were subjected for biopharmaceutical studies, analgesic, anti-inflammatory activities and ulcerogenic index. Marked reduction of ulcerogenic index and comparable analgesic, anti-inflammatory activities were obtained in all cases as compared to KC. Among synthesized prodrugs, viz. AR-11, AR-19 and AR-20 showed excellent pharmacological response and encouraging hydrolysis rate both in SIF and in 80% human plasma. Prodrugs with increased aliphatic side chain length or introduction of aromatic substituent showed enhanced partition coefficient but diminished dissolution and hydrolysis rates. Such prodrugs can be considered for sustained release purpose.