1093409-44-9Relevant academic research and scientific papers
Synthesis of tetracyclic dioxygenated isoquinolines and their cytotoxic activity
Romero, Manel,Caignard, Daniel-Henry,Renard, Pierre,Pujol, M. Dolors
, p. 11020 - 11027 (2008)
An efficient synthesis of new dioxygenated isoquinolines is reported. The novelty of this approach derives from its use of tricyclic-nitril (3) as a building block in a synthetic sequence of seven steps for the preparation of the tetracyclic isoquinoline (14) and its derivatives. The isoquinoline 16 was 10-fold more active against leukemia L1210 than the corresponding tetrahydroisoquinoline 14.
