109342-22-5

Upstream product

• 29079-00-3 4-ethynyl-1,1'-biphenyl 
• 92-91-1 biphenyl-4-acetaldehyde 
• 92600-09-4 3,3-dimercapto-1-(4-biphenyl)-2-propen-1-one 

Downstream Products

• 155816-32-3 (5-Biphenyl-4-yl-3-mercapto-3H-[1,2]dithiol-3-yl)-bromo-acetic acid ethyl ester 
• 181058-28-6 8-Biphenyl-4-yl-3-(4-nitro-phenyl)-1-oxa-4,6,7-trithia-2-aza-spiro[4.4]nona-2,8-diene 

Relevant academic research and scientific papers

Method for synthesizing 1,2-disulfide-3-thioketone derivative by using copper to catalyze

The invention relates to a method for synthesizing 1,2-disulfide-3-thioketone derivative by copper-catalyzed propargylamine sulfur cyclization, and the method comprises the following steps: N, N-dimethyl-3-phenyl propyl-2-alkynyl-1-amine is taken as a substrate, cuprous chloride, cuprous bromide or cuprous iodide is added into the substrate to serve as a catalyst, potassium phosphate, sodium bicarbonate or sodium acetate is taken as an alkali, elemental sulfur is taken as a sulfur source, stirring reaction is performed in a solvent for 12 hours at the temperature of 100-120 DEG C. The elemental sulfur is used as the sulfur source, and the method has the advantages of simple and easily available raw materials, simple reaction operation, relatively mild conditions, wide substrate universality, relatively high yield and good functional group compatibility.

Copper-Catalyzed Tandem Sulfuration/Annulation of Propargylamines with Sulfur via C-N Bond Cleavage

Copper-catalyzed aerobic oxidative sulfuration and annulation of propargylamines with elemental sulfur is described. The tandem reaction involves C-N bond cleavage and the formation of multiple C-S bonds, affording 1,2-dithiole-3-thiones in good to excellent yields with good functional group tolerance.

Copper-Catalyzed Defluorinative Thioannulation of Trifluoropropynes for the Synthesis of 1,2-Dithiole-3-thiones

A simple and practical strategy for the preparation of 1,2-dithiole-3-thiones via copper-catalyzed defluorinative thioannulation of trifluoropropynes has been developed using elemental sulfur as the sole sulfur source. This reaction displays a wide substrate scope and high functional group tolerance to afford the corresponding S-heterocycles in moderate to good yields and features efficient construction of multiple C?S bonds through C?F bond cleavage of CF3 groups. (Figure presented.).

Ketoken gem-dithiols and trithiones: Synthesis and study of the behavior towards dipole reagents; Synthesis of some nitrogen heteroaromatics

The behavior of ketoken gem-dithiols towards active methylene and methyl groups resulted in the formation of thiopyrano-dihydrocaumarine derivatives IIIa,b via cyclocondensation reaction between substituted 4-dihydrocyclohexanone Ia.b. N-phenylpyrazoline

KETOKETEN gem-DITHIOLS: SYNTHESIS OF SEVERAL SULFUR HETEROCYCLES

Reduction of the disaurine 1 in two different reaction conditions gave products 2 and 3.Hydrazine hydrate reacted with 1 to give the adduct 4.Sulfurization of 1 or 6 with P4S10 yielded the trithione 5.Reaction of 5 and 6 with several reagents yielded the