109352-73-0Relevant academic research and scientific papers
Synthesis of 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]quinoline-1,4, 10(5H)-triones as NMDA glycine-site antagonists
Brown, Dean G.,Urbanek, Rebecca A.,Bare, Thomas M.,McLaren, Frances M.,Horchler, Carey L.,Murphy, Megan,Steelman, Gary B.,Empfield, James R.,Forst, Janet M.,Herzog, Keith J.,Xiao, Wenhua,Dyroff, Martin C.,Lee, Chi-Ming C.,Trivedi, Shephali,Neilson, Kathy L.,Keith, Richard A.
, p. 3553 - 3556 (2007/10/03)
Several members of the 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]quinoline-1,4, 10(5H)-triones (2) have been identified as being potent and selective NMDA glycine-site antagonists. Increasing size of the alkyl substituent on the alpha-c
Anthelmintic pyridinyl acylhydrazones derivatives
-
, (2008/06/13)
This invention concerns a process for killing internal parasites, especially nematodes and cestodes affecting warm blooded animals such as sheep, cattle, swine, goats, dogs, cats, horses and humans as well as poultry by administering an effective amount of a compound of the Formula I: STR1 Certain of the compounds of Formula I are novel and in further embodiments of the invention provide novel compounds and compositions for use in the process of the invention. The compounds are readily prepared by conventional chemical reactions. Various pyridinyl acylhydrazones of Formula I demonstrate broad-spectrum anthelmintic activity in sheep upon oral and/or parenteral administration.
