1093643-64-1Relevant academic research and scientific papers
Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656)
Li, Xianfeng,Hernandez, Vincent,Rock, Fernando L.,Choi, Wai,Mak, Yvonne S. L.,Mohan, Manisha,Mao, Weimin,Zhou, Yasheen,Easom, Eric E.,Plattner, Jacob J.,Zou, Wuxin,Pérez-Herrán, Esther,Giordano, Ilaria,Mendoza-Losana, Alfonso,Alemparte, Carlos,Rullas, Joaquín,Angulo-Barturen, I?igo,Crouch, Sabrinia,Ortega, Fátima,Barros, David,Alley
, p. 8011 - 8026 (2017/10/18)
There is an urgent need to develop new and safer antitubercular agents that possess a novel mode of action. We synthesized and evaluated a novel series of 3-aminomethyl 4-halogen benzoxaboroles as Mycobacterium tuberculosis (Mtb) leucyl-tRNA synthetase (L
TRICYCLIC BENZOXABOROLE COMPOUNDS AND USES THEREOF
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, (2015/02/25)
Compounds of Formula II wherein X is selected from chloro, fluoro, bromo and iodo, R1 and R2 are each independently selected from H, -CH3, -CH2CH3, -CH2CH2CH3, or -CH(CH3)2
BORON-CONTAINING SMALL MOLECULES
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Page/Page column 152, (2009/01/23)
This invention provides, among other things, novel compounds useful for treating bacterial infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
