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Relevant academic research and scientific papers

Single-pot access to bisorganoborinates: Applications in zweifel olefination

Zweifel olefination is a catalyst-free reaction that serves alkene functionalization. While most methods employ commercially available boron pinacol esters, we have assembled a sequence in which the two partners of the formal coupling reaction are installed successively, starting from inexpensive boron alkoxides. The in situ formation of bisorganoborinates was accomplished by consecutive reaction of two different organometallic species. This single-pot procedure represents a great advancement in the generation of organoborinates and their involvement in C-C bond formation.

Synthetic method of 1,1-diarylethenes derivative

The invention discloses a synthetic method of a 1,1-diarylethenes derivative. The synthetic method comprises the following steps: with cinnamic acid derivatives and aryltriethoxysilane as raw materials, mixing the raw materials with a catalyst, an oxidizing agent, a ligand, an additive and alkali; carrying out reaction for 2 to 24 hours at 100 to 160 DEG C under argon protection in a reaction solvent so as to prepare a target compound. Because cinnamic acid is common unsaturated carboxylic acid, the preparation is convenient, cinnamic acid is cheap and easy to obtain; because aryltriethoxysilane is common organosilane in organic chemistry, aryltriethoxysilane is cheap and easy to obtain, is higher in stability and has little impact on an environment; therefore, the 1,1-diarylethenes derivative is synthesized by carrying out coupled reaction between the selected aryltriethoxysilane and the cinnamic acid derivatives. The synthetic method has the advantages of cheap and easy availabilityof the raw materials and low production cost; meanwhile, an experiment is easy to operate, and the synthetic method can be developed as an industrialized production method. According to the syntheticmethod disclosed by the invention, synthetic conditions are also screened and optimized, so that the reaction yield is further improved.

α,α-Diarylethylene Glycols as Valuable Precursor for Synthesis of 1,1-Diarylethenes and α,α-Diaryl Acetaldehydes

Towards assembling of diarylmethine unit present in biologically important molecules, we have developed a new Weinreb Amide (WA) based building block derived from glycolic acid. The WA functionality present in this building block permits the sequential addition of various arylmagnesium bromide reagents in a controlled manner that enables assembly of a diarylmethine unit. The developed synthetic route provides easy access to important diarylethenes and α,α-diarylethylene glycols. The synthesized α,α-diarylethylene glycols provide access to synthetically important symmetrical and unsymmetrical α,α-diaryl acetaldehydes as valuable intermediates.