1093653-03-2Relevant academic research and scientific papers
Photoactivated DNA cleavage and anticancer activity of pyrenyl-terpyridine lanthanide complexes
Hussain, Akhtar,Gadadhar, Sudarshan,Goswami, Tridib K.,Karande, Anjali A.,Chakravarty, Akhil R.
, p. 319 - 331 (2012)
Lanthanide(III) complexes [Ln(R-tpy)(acac)(NO3)2] (Ln = La(III) in 1, 2; Gd(III) in 4, 5) and [Ln(py-tpy)(sacac)(NO3) 2] (Ln = La(III), 3; Gd(III), 6), where R-tpy is 4′-phenyl-2, 2′:6′,2″-terpyridine (ph-tpy in 1, 4), 4′-(1-pyrenyl)-2, 2′:6′,2″-terpyridine (py-tpy in 2, 3, 5 and 6), acac is acetylacetonate and sacac is 4-hydroxy-6-{4-[(β-d-glucopyranoside)oxy] phenyl}hex-3,5-dien-2-onate, were prepared to study their DNA photocleavage activity and photocytotoxicity. Complexes [La(ph-tpy)(acac)(EtOH)(NO 3)2] (1a) and [Gd(ph-tpy)(acac)(NO3) 2] (4) were characterized by X-ray crystallography. The 1:1 electrolytic complexes bind to calf thymus DNA. The py-tpy complexes cleave pUC19 DNA and exhibit remarkable photocytotoxicity in HeLa cells in UV-A light of 365 nm with apoptotic cell death (IC50: ～40 nM in light, >200 μM in dark). Confocal microscopy using HeLa cells reveal primarily cytosolic localization of the complexes.
