1093653-29-2Relevant academic research and scientific papers
METHODS FOR THE SYNTHESIS OF 4-HYDROXYISOLEUCINE, STEREOISOMERS AND ANALOGS THEREOF
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Page/Page column 28, (2009/01/24)
A method for synthesizing 4-hydroxyisoleucine, stereoisomers and analogs thereof having a general formula I is disclosed herein. The method comprises reacting an alkyl isocyanoacetate of formula III with an acetoin or an acetoin analog of formula II to give an unsaturated N-formyl lactone of formula IV, hydrogenating the unsaturated N-formyl lactone to give N-formyl lactone of formula V and hydrolysing said lactone to yield the desired product of formula I.
