1093661-46-1

Basic information

• Product Name: (2R,3R,6E,8S,10S)-1-(4-hydroxyphenyl)-8,10-dimethyl-2-(methylamino)dodec-6-en-3-ol
• Synonyms: (2R,3R,6E,8S,10S)-1-(4-hydroxyphenyl)-8,10-dimethyl-2-(methylamino)dodec-6-en-3-ol
• CAS NO: 1093661-46-1
• Molecular Weight: 333.514
• Mol File: 1093661-46-1.mol

Chemical Properties

• CAS DataBase Reference: (2R,3R,6E,8S,10S)-1-(4-hydroxyphenyl)-8,10-dimethyl-2-(methylamino)dodec-6-en-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R,6E,8S,10S)-1-(4-hydroxyphenyl)-8,10-dimethyl-2-(methylamino)dodec-6-en-3-ol(1093661-46-1)
• EPA Substance Registry System: (2R,3R,6E,8S,10S)-1-(4-hydroxyphenyl)-8,10-dimethyl-2-(methylamino)dodec-6-en-3-ol(1093661-46-1)

Safety Data

• Hazardous Substances Data: 1093661-46-1(Hazardous Substances Data)

Upstream product

• 1159215-70-9 tert-butyl (1R,2R,5E,7S,9S)-[2-(tert-butyldimethylsilyloxy)-1-[4-(methoxymethoxy)benzyl]-7,9-dimethylundec-5-enyl]methylcarbamate 
• 1246843-24-2 C₃₀H₅₁NO₄ 
• 1093169-21-1 C₃₂H₅₅NO₆ 

Relevant articles and documents

Total synthesis and biological evaluation of tyroscherin

Figure Presented. The efficient synthesis and biological evaluation of both the reported and revised structures of tyroscherin have been achieved. Central to our synthesis is a cross metathesis reaction that generated the trans-olefin regioselectively. Th

Synthesis and structure revision of tyroscherin, and bioactivities of its stereoisomers against IGF-1-dependent tumor cells

Synthesis of the proposed structure of tyroscherin, a growth inhibitor of IGF-1-dependent cancer cells, was succeeded by one-pot Julia coupling. However, spectral data of the synthetic compound were not identical with those of natural tyroscherin. The stereochemistry of tyroscherin is revised to be 2S,3R,8R,10R by syntheses of stereoisomers. Synthetic tyroscherin showed more potent activity than its stereoisomers against IGF-1-dependent cancer cells.

Synthesis and structure revision of tyroscherin, a growth inhibitor of IGF-1-dependent tumor cells

Synthesis of the proposed structure of tyroscherin, a growth inhibitor of IGF-1-dependent cancer cells, was succeeded by one-pot Julia coupling. However, spectral data of the synthetic compound were not identical with those of natural tyroscherin. The stereochemistry of tyroscherin was revised to be 2S,3R,8R,10R by syntheses of stereoisomers.