1093748-40-3

Upstream product

• 33528-09-5 methyl 6-methylsalicylate 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 1093748-41-4 methyl 2-(tert-butyldimethylsilyloxy)-6-(bromomethyl)-benzoate 
• 1448250-96-1 cis-(1aS,7bR)-5-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylmethyl]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid 
• 1448250-97-2 cis-(1aR,7bS)-5-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylmethyl]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid 
• 1448251-05-5 methyl 2-hydroxy-6-methoxymethylbenzoate 
• 1448251-04-4 methyl 2-methoxymethyl-6-propargyloxybenzoate 

Relevant academic research and scientific papers

Titanocene(III) chloride mediated radical-induced synthesis of 3,4-dihydroisocoumarins: synthesis of (±)-hydrangenol, (±)-phyllodulcin, (±)-macrophyllol and (±)-thunberginol G

A radical-promoted synthesis of 3,4-dihydroisocoumarins has been achieved in moderate to good yields using titanocene(III) chloride (Cp2TiCl) as the radical initiator. The total synthesis of four naturally occurring dihydrocoumarins hydrangenol, phyllodulcin, macrophyllol and thunberginol G has been accomplished using the radical technology. Cp2TiCl was prepared in situ from commercially available titanocene dichloride (Cp2TiCl2) and Zn-dust in THF under argon.

TRICYCLIC SULFONE COMPOUNDS AND METHODS OF MAKING AND USING SAME

The invention provides tricyclic sulfone compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity ag