109376-83-2 Usage
Uses
Used in Pharmaceutical Industry:
ML-7 HYDROCHLORIDE is used as a potent and selective inhibitor for myosin light chain kinase (MLCK) for its ability to modulate cellular processes and potentially treat conditions related to abnormal muscle contractions and cell motility.
Used in Research Applications:
ML-7 HYDROCHLORIDE is used as a research tool for studying the role of myosin light chain kinase in various cellular processes, including cell signaling, cell migration, and muscle contraction. Its selective inhibition of MLCK allows researchers to investigate the specific functions and pathways involving this enzyme.
Used in Drug Development:
ML-7 HYDROCHLORIDE serves as a starting point for the development of new drugs targeting myosin light chain kinase, which may have therapeutic applications in treating conditions such as smooth muscle disorders, cardiovascular diseases, and certain types of cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 109376-83-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,9,3,7 and 6 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 109376-83:
(8*1)+(7*0)+(6*9)+(5*3)+(4*7)+(3*6)+(2*8)+(1*3)=142
142 % 10 = 2
So 109376-83-2 is a valid CAS Registry Number.
InChI:InChI=1/C15H17IN2O2S/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18/h1-2,4-7,17H,3,8-11H2
109376-83-2Relevant academic research and scientific papers
Bhadoria, Rohit,Lohk, Christer,Ping, Kefeng,Starkov, Pavel,J?rving, Ivar
, p. 4216 - 4219 (2020)
Various conjugation techniques are used to affect the intracellular delivery of bioactive small molecules. However, the ability to track changes in the phenotype when applying these tools remains poorly studied. We addressed this issue by having prepared a focused library of heterobivalent constructs based on Rho kinase inhibitor HA-100. By comparing the induction of the phenotype of interest, cell viability and cellular uptake, we demonstrate that various conjugates indeed lead to divergent cellular outcomes.
