109376-83-2 Usage
Uses
A potent and selective inhibitor of myosin light chain kinase.
Definition
ChEBI: An N-sulfonyldiazepane resullting from the formal condensation of 5-iodo-1-naphthylsulfonic acid with one of the nitrogens of 1,4-diazepane. It is a selective inhibitor of myosin light chain kinase (EC 2.7.11.18).
Check Digit Verification of cas no
The CAS Registry Mumber 109376-83-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,9,3,7 and 6 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 109376-83:
(8*1)+(7*0)+(6*9)+(5*3)+(4*7)+(3*6)+(2*8)+(1*3)=142
142 % 10 = 2
So 109376-83-2 is a valid CAS Registry Number.
InChI:InChI=1/C15H17IN2O2S/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18/h1-2,4-7,17H,3,8-11H2
109376-83-2Relevant articles and documents
A phenotypic approach to probing cellular outcomes using heterobivalent constructs
Bhadoria, Rohit,Lohk, Christer,Ping, Kefeng,Starkov, Pavel,J?rving, Ivar
, p. 4216 - 4219 (2020)
Various conjugation techniques are used to affect the intracellular delivery of bioactive small molecules. However, the ability to track changes in the phenotype when applying these tools remains poorly studied. We addressed this issue by having prepared a focused library of heterobivalent constructs based on Rho kinase inhibitor HA-100. By comparing the induction of the phenotype of interest, cell viability and cellular uptake, we demonstrate that various conjugates indeed lead to divergent cellular outcomes.
