1093791-66-2Relevant academic research and scientific papers
Synthesis and SAR study of T-type calcium channel blockers. Part II
Yun, Jeong Choe,Han, Na Seo,Soo, Yeon Jung,Rhim, Hyewhon,Kim, Jungahn,Dong, Joon Choo,Jae, Yeol Lee
, p. 661 - 664 (2008)
3,4-Dihydroquinazoline derivatives have been known to be the novel and potent T-type calcium channel blockers. From a systematic variation of 3,4-dihydroquinazoline derivative 5c (KYS05043), plausible SAR results were established. It was revealed that a 5-(dimethylamino)pentylamino group at R 1, a biphenyl group at R2, and a benzyl amido group at R3 in the 3,4-dihydroquinazoline backbone are closely related with the channel selectivity (T/N-type) as well as the potency based on the discovery of 6k (KYS05090).
