1093798-74-3Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of quinazoline derivatives as dual HDAC1 and HDAC6 inhibitors for the treatment of cancer
Chen, Jinying,Sang, Zitai,Jiang, Youjun,Yang, Chao,He, Linhong
, p. 232 - 241 (2018/11/02)
Fifty-eight quinazoline-based compounds were designed and synthesized based on the structural optimizations from the lead compound 23bb in an attempt to search for more potent dual HDAC1 and HDAC6 inhibitors. Among them, 32c (HDAC1, IC50?=?31.1
Discovery of Selective Histone Deacetylase 6 Inhibitors Using the Quinazoline as the Cap for the Treatment of Cancer
Yang, Zhuang,Wang, Taijin,Wang, Fang,Niu, Ting,Liu, Zhuowei,Chen, Xiaoxin,Long, Chaofeng,Tang, Minghai,Cao, Dong,Wang, Xiaoyan,Xiang, Wei,Yi, Yuyao,Ma, Liang,You, Jingsong,Chen, Lijuan
, p. 1455 - 1470 (2016/03/08)
Novel selective histone deacetylase 6 (HDAC6) inhibitors using the quinazoline as the cap were designed, synthesized, and evaluated for HDAC enzymatic assays. N-Hydroxy-4-(2-methoxy-5-(methyl(2-methylquinazolin-4-yl)amino)phenoxy)butanamide, 23bb, was the
PYRROLOPYRIMIDINES
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Page/Page column 50, (2009/03/07)
The present invention relates to compounds or pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy. The invention particularly relates to compounds that are polo-like kinase (PLKs) inhibitors useful for the treatment of disease states mediated by PLK, especially PLK4, in particular such compounds that are useful in the treatment of pathological processes which involve an aberrant cellular proliferation, such as tumour growth, rheumatoid arthritis, restenosis and atherosclerosis.
INDOLIN-2-ONES AND AZA-INDOLIN-2-ONES
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Page/Page column 66, (2009/01/23)
The present invention relates to compounds or pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy. The invention particularly relates to certain indolin- 2-ones and aza-indolin-2-ones which possess anti-tumour activity and are accordingly useful in methods of treatment of the human or animal body, in particular such compounds are useful in the treatment of pathological processes which involve an aberrant cellular proliferation, such as tumor growth, rheumatoid arthritis, restenosis and atherosclerosis.
