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Product FOB Price Min.Order Supply Ability Supplier
N-BOC-4-Hydroxypiperidine,98%
Cas No: 109384-19-2
USD $ 150.0-250.0 / Kilogram 1 Kilogram 5 Metric Ton/Month Anhui Dexinjia Biopharm Co., Ltd Contact Supplier
99% White Powder CAS 109384-19-2 N-BOC-4-Hydroxypiperidine
Cas No: 109384-19-2
USD $ 9.0-10.0 / Kilogram 1 Kilogram 500 Metric Ton/Month Shanlong Biotechnology (hebei) Co., Ltd. Contact Supplier
CAS:109384-19-2 N-BOC-4-Hydroxypiperidine
Cas No: 109384-19-2
No Data 1 Kilogram 100 Kilogram/Week Kono Chem Co.,Ltd Contact Supplier
1-Boc-4-piperidinol
Cas No: 109384-19-2
No Data 1 Kilogram 20 Metric Ton/Week Henan Allgreen Chemical Co.,Ltd Contact Supplier
N-Boc-4-Hydroxypiperidine manufacturer
Cas No: 109384-19-2
No Data No Data 3000 Kilogram/Month ORCHID CHEMICAL SUPPLIES LTD Contact Supplier
1-Boc-4-Hydroxypiperidine
Cas No: 109384-19-2
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
N-tert-Butoxycarbonyl-4-piperidinol
Cas No: 109384-19-2
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
N-BOC-4-Hydroxypiperidine
Cas No: 109384-19-2
No Data No Data No Data Shanghai Sunwise Chemical Co., Ltd Contact Supplier
N-BOC-4-Hydroxypiperidine
Cas No: 109384-19-2
USD $ 2.0-2.0 / Kilogram 1 Kilogram 1-10 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
N-BOC-4-Hydroxypiperidine 109384-19-2
Cas No: 109384-19-2
No Data 1 Kilogram 100 Metric Ton/Day Henan Tianfu Chemical Co., Ltd. Contact Supplier

109384-19-2 Usage

Uses

N-Boc-4-hydroxypiperidine is a 4-hydroxypyridine with a boc protecting group used in the preparation of neurologically active agents and other pharmaceutical compounds.

Chemical Properties

White to cream powder
InChI:InChI=1/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-8(12)5-7-11/h8,12H,4-7H2,1-3H3

109384-19-2 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Aldrich (495484)  1-Boc-4-hydroxypiperidine  97% 109384-19-2 495484-25G 1,490.58CNY Detail
Aldrich (495484)  1-Boc-4-hydroxypiperidine  97% 109384-19-2 495484-5G 452.79CNY Detail

109384-19-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name N-BOC-4-Hydroxypiperidine

1.2 Other means of identification

Product number -
Other names 1-Boc-4-piperidinol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:109384-19-2 SDS

109384-19-2Synthetic route

4-HYDROXYPIPERIDINE
5382-16-1

4-HYDROXYPIPERIDINE

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions
ConditionsYield
With sodium hydroxide In water; tert-butyl alcohol at 20℃;100%
With sodium carbonate In dichloromethane; water for 72h;100%
With sodium carbonate In dichloromethane; water for 72h; Inert atmosphere;100%
N-tert-butyloxycarbonylpiperidin-4-one
79099-07-3

N-tert-butyloxycarbonylpiperidin-4-one

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions
ConditionsYield
With sodium tetrahydroborate In ethanol100%
Stage #1: N-tert-butyloxycarbonylpiperidin-4-one With sodium tetrahydroborate In ethanol at 0 - 20℃; for 4h;
Stage #2: With water; ammonium chloride In ethanol
100%
With sodium hydroxide; sodium borohydrid In methanol100%
4-HYDROXYPIPERIDINE
5382-16-1

4-HYDROXYPIPERIDINE

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions
ConditionsYield
With tert-butyldicarbonate; triethylamine In dichloromethane at 0℃; for 21h;100%
4-HYDROXYPIPERIDINE
5382-16-1

4-HYDROXYPIPERIDINE

tert-butyldicarbonate
34619-03-9

tert-butyldicarbonate

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions
ConditionsYield
With sodium hydrogencarbonate In dichloromethane for 15h;100%
In tetrahydrofuran at 20℃;98.3%
With triethylamine In tetrahydrofuran at 20℃;98.3%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

piperidin-4-ol hydrochloride
5382-17-2

piperidin-4-ol hydrochloride

sodium hydrogencarbonate
144-55-8

sodium hydrogencarbonate

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions
ConditionsYield
In 1,4-dioxane100%
In 1,4-dioxane100%
pyridin-4-ol
626-64-2

pyridin-4-ol

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: pyridin-4-ol With chloro(1,5-cyclooctadiene)rhodium(I) dimer; borane-ammonia complex In 2,2,2-trifluoroethanol at 50℃; for 24h; Inert atmosphere; Schlenk technique; Sealed tube;
Stage #2: di-tert-butyl dicarbonate With triethylamine In 2,2,2-trifluoroethanol at 20℃; Inert atmosphere; Schlenk technique; Sealed tube;
99%
4-HYDROXYPIPERIDINE
5382-16-1

4-HYDROXYPIPERIDINE

carbon monoxide
201230-82-2

carbon monoxide

tert-butyl alcohol
75-65-0

tert-butyl alcohol

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions
ConditionsYield
With 2C7H9N4*Au(1+)*Cu(1+)*2I(1-) In toluene at 90℃; for 8h; Autoclave;98%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran; ethyl acetate95%
Multi-step reaction with 2 steps
1: triethylamine / water; 1,4-dioxane / 0 - 20 °C
2: sodium tetrahydroborate; methanol / 0 - 20 °C
View Scheme
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 0.8 h / 0 - 20 °C
2: sodium tetrahydroborate; methanol / 0.01 h / 0 - 20 °C
View Scheme
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

A

t-butyl piperidinecarboxylate
75844-69-8

t-butyl piperidinecarboxylate

B

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran; ethyl acetateA n/a
B 94%
With triethylamine In tetrahydrofuran; ethyl acetateA n/a
B 94%
With triethylamine In tetrahydrofuran; ethyl acetateA n/a
B 94%
tert-butyl 4-((4-methoxybenzyl)oxy)piperidine-1-carboxylate
1311186-22-7

tert-butyl 4-((4-methoxybenzyl)oxy)piperidine-1-carboxylate

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions
ConditionsYield
With N,N,N,N-tetraethylammonium tetrafluoroborate In methanol Electrochemical reaction;81%
t-butyl piperidinecarboxylate
75844-69-8

t-butyl piperidinecarboxylate

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions
ConditionsYield
With D-glucose; cells of Sphingomonas sp. HXN-200 In phosphate buffer at 30℃; for 2h; pH=8.0;69.5%
4-[(1-{tert-butoxycarbonyl}-4-piperidinyl)oxy]-1-(1-methylethyl)pyridinium iodide
845305-79-5

4-[(1-{tert-butoxycarbonyl}-4-piperidinyl)oxy]-1-(1-methylethyl)pyridinium iodide

A

tert-butyl 4-{[1-(1-methylethyl)-4-piperidinyl]oxy}-1-piperidinecarboxylate
845305-80-8

tert-butyl 4-{[1-(1-methylethyl)-4-piperidinyl]oxy}-1-piperidinecarboxylate

B

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions
ConditionsYield
With platinum (IV) oxide; hydrogen In ethanol at 20℃; under 2587.76 Torr; for 144h;A 54%
B 20%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

piperidin-4-ol hydrochloride
5382-17-2

piperidin-4-ol hydrochloride

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions
ConditionsYield
With sodium hydroxide In water at 25℃; for 1h;
Methoxyallene
13169-00-1

Methoxyallene

N-tert-butyloxycarbonylpiperidin-4-one
79099-07-3

N-tert-butyloxycarbonylpiperidin-4-one

A

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

B

N-(tert-butoxycarbonyl)-4-[(Z)-3-methoxyprop-2-enyl]piperidin-4-ol

N-(tert-butoxycarbonyl)-4-[(Z)-3-methoxyprop-2-enyl]piperidin-4-ol

C

N-(tert-butoxycarbonyl)-4-[(E)-3-methoxyprop-2-enyl]piperidin-4-ol

N-(tert-butoxycarbonyl)-4-[(E)-3-methoxyprop-2-enyl]piperidin-4-ol

Conditions
ConditionsYield
With N,N,N,N,N,N-hexamethylphosphoric triamide; samarium diiodide; tert-butyl alcohol In tetrahydrofuran at 20℃; Title compound not separated from byproducts;
C13H18BrN3O2
950848-59-6

C13H18BrN3O2

N-tert-butyloxycarbonylpiperidin-4-one
79099-07-3

N-tert-butyloxycarbonylpiperidin-4-one

A

C23H35BrN4O4
950848-60-9

C23H35BrN4O4

B

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: C18H26BrN3O4 With trifluoroacetic acid In dichloromethane for 0.5h;
Stage #2: C13H18BrN3O2; N-tert-butyloxycarbonylpiperidin-4-one With sodium tris(acetoxy)borohydride; triethylamine In 1,2-dichloro-ethane at 20℃; for 16h;
Stage #3: With water; sodium hydrogencarbonate In dichloromethane; 1,2-dichloro-ethane
sodium potassium tartrate tetrahydrate

sodium potassium tartrate tetrahydrate

N-tert-butyloxycarbonylpiperidin-4-one
79099-07-3

N-tert-butyloxycarbonylpiperidin-4-one

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions
ConditionsYield
With diisobutylaluminium hydride In tetrahydrofuran; toluene
3-(1-tert-butoxycarbonylpiperidin-4-yloxy)benzoic acid
250681-69-7

3-(1-tert-butoxycarbonylpiperidin-4-yloxy)benzoic acid

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

titanium(IV) isopropylate
546-68-9

titanium(IV) isopropylate

N-tert-butyloxycarbonylpiperidin-4-one
79099-07-3

N-tert-butyloxycarbonylpiperidin-4-one

2-phenyl-3-keto-piperazine
5368-28-5

2-phenyl-3-keto-piperazine

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions
ConditionsYield
With sodium cyanoborohydride In methanol
4-[3-(N-BOC-Piperidin-4-yl)propyl]benzoic acid
163210-39-7

4-[3-(N-BOC-Piperidin-4-yl)propyl]benzoic acid

A

4-[3-(Piperidin-4-yl)propyl]benzoyl-2(S)-phenyl-sulfonylamino-β-alanine

4-[3-(Piperidin-4-yl)propyl]benzoyl-2(S)-phenyl-sulfonylamino-β-alanine

B

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

4-piperidone monohydrochloride monohydrate
40064-34-4

4-piperidone monohydrochloride monohydrate

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions
ConditionsYield
With sodium borohydrid; N-ethyl-N,N-diisopropylamine In N-methyl-acetamide; ethanol; water
4-HYDROXYPIPERIDINE
5382-16-1

4-HYDROXYPIPERIDINE

3-(1-tert-butoxycarbonylpiperidin-4-yloxy)benzoic acid
250681-69-7

3-(1-tert-butoxycarbonylpiperidin-4-yloxy)benzoic acid

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions
ConditionsYield
With triethylamine In dichloromethane
4-HYDROXYPIPERIDINE
5382-16-1

4-HYDROXYPIPERIDINE

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

A

4-[(1H-benzimidazol-2-ylmethyl)-(5,6,7,8-tetrahydroquinolin-8-yl)-amino]-piperidine-1-carboxylic Acid Amide (Hydrobromide Salt)
558448-73-0

4-[(1H-benzimidazol-2-ylmethyl)-(5,6,7,8-tetrahydroquinolin-8-yl)-amino]-piperidine-1-carboxylic Acid Amide (Hydrobromide Salt)

B

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions
ConditionsYield
In tetrahydrofuran
(R)-1-cyclohexyl-4-phenyl-3-(piperidin-4-yl)imidazolidin-2-one
926291-23-8

(R)-1-cyclohexyl-4-phenyl-3-(piperidin-4-yl)imidazolidin-2-one

N-tert-butyloxycarbonylpiperidin-4-one
79099-07-3

N-tert-butyloxycarbonylpiperidin-4-one

A

4-((R)-3-cyclohexyl-2-oxo-5-phenyl-imidazolidin-1-yl)-[1,4']bipiperidinyl-1'-carboxylic acid tert-butyl ester
1032818-37-3

4-((R)-3-cyclohexyl-2-oxo-5-phenyl-imidazolidin-1-yl)-[1,4']bipiperidinyl-1'-carboxylic acid tert-butyl ester

B

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions
ConditionsYield
With sodium cyanoborohydride; acetic acid In methanol at 60℃; for 16h;
4-HYDROXYPIPERIDINE
5382-16-1

4-HYDROXYPIPERIDINE

tert-butyl chloroformate
24608-52-4

tert-butyl chloroformate

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions
ConditionsYield
With triethylamine
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

4-hydroxypiperazine
69395-49-9

4-hydroxypiperazine

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 5h;34 g
tert-butyl 4-(tosyloxy)piperidin-1-carboxylate
118811-07-7

tert-butyl 4-(tosyloxy)piperidin-1-carboxylate

C9H15ClMg
245507-96-4

C9H15ClMg

A

C19H33NO2

C19H33NO2

B

N-Boc-1,2,3,6-tetrahydropyridine
85838-94-4

N-Boc-1,2,3,6-tetrahydropyridine

C

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions
ConditionsYield
With dilithium tetrachlorocuprate In tetrahydrofuran at 40℃;
1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate
141699-59-4

1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate

C9H15ClMg
245507-96-4

C9H15ClMg

A

C19H33NO2

C19H33NO2

B

N-Boc-1,2,3,6-tetrahydropyridine
85838-94-4

N-Boc-1,2,3,6-tetrahydropyridine

C

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions
ConditionsYield
With copper dichloride In tetrahydrofuran at 20℃;
p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

tert-butyl 4-(tosyloxy)piperidin-1-carboxylate
118811-07-7

tert-butyl 4-(tosyloxy)piperidin-1-carboxylate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 20h;100%
at 20℃; for 20h;99%
With triethylamine In dichloromethane at 20℃;89%
methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate
141699-59-4

1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 5℃; for 3h;100%
With triethylamine In dichloromethane at 0 - 20℃; for 2.16667h;100%
With triethylamine In dichloromethane at 0 - 20℃; for 2.16667h;100%
acetic anhydride
108-24-7

acetic anhydride

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

2-methylpropan-2-yl 4-(acetyloxy)piperidine-1-carboxylate
850452-53-8

2-methylpropan-2-yl 4-(acetyloxy)piperidine-1-carboxylate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 5h;100%
With dmap; triethylamine In dichloromethane at 0 - 20℃;55.17%
In pyridine at 25℃; for 6h;
With pyridine at 20℃;3 g
With pyridine at 20℃; for 5h;3 g
2-fluorobenzonitrile
394-47-8

2-fluorobenzonitrile

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

4-(2-cyano-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester
647014-70-8

4-(2-cyano-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide at 20 - 50℃;100%
With (E)-[4-(hydroxy)piperidin-1-ylsulphonyl]-2-(3-pyridyl)ethene In DMF (N,N-dimethyl-formamide) for 15h;
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 2h;
Stage #2: 2-fluorobenzonitrile at 50℃; for 1h;
1-chloroisoquinoline
19493-44-8

1-chloroisoquinoline

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

1-tert-butoxycarbonyl-4-(1-isoquinolinyloxy)-piperidine
817187-34-1

1-tert-butoxycarbonyl-4-(1-isoquinolinyloxy)-piperidine

Conditions
ConditionsYield
With crown ether; potassium tert-butylate In DMF (N,N-dimethyl-formamide) at 20℃;100%
salicylonitrile
611-20-1

salicylonitrile

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

2-(piperidin-4-yloxy)-benzonitrile hydrochloride

2-(piperidin-4-yloxy)-benzonitrile hydrochloride

Conditions
ConditionsYield
Stage #1: salicylonitrile; t-butyl 4-hydroxy piperidine-1-carboxylate With di-tert-butyl-diazodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 18h;
Stage #2: With hydrogenchloride; water In 1,4-dioxane at 20℃; for 18h;
100%
4-chlorpyridine hydrochloride
7379-35-3

4-chlorpyridine hydrochloride

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

2-(piperidin-4-yloxy)pyridine
127806-46-6

2-(piperidin-4-yloxy)pyridine

Conditions
ConditionsYield
In tetrahydrofuran; dimethyl sulfoxide100%
In tetrahydrofuran; dimethyl sulfoxide100%
In tetrahydrofuran; dimethyl sulfoxide100%
4-(4-chlorophenoxy)phenol
21567-18-0

4-(4-chlorophenoxy)phenol

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

tert-butyl 4-[4-(4-chloro-phenoxy)-phenoxy]-piperidine-1-carboxylate

tert-butyl 4-[4-(4-chloro-phenoxy)-phenoxy]-piperidine-1-carboxylate

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 47℃; for 65.1667h;100%
2-(4-hydroxyphenyl)-5-methyl-2H-pyrazole-3-carboxylic acid cyclohexylamide
946859-60-5

2-(4-hydroxyphenyl)-5-methyl-2H-pyrazole-3-carboxylic acid cyclohexylamide

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

4-[4-(5-cyclohexylcarbamoyl-3-methylpyrazol-1-yl)phenoxy]piperidine-1-carboxylic acid tert-butyl ester
946859-61-6

4-[4-(5-cyclohexylcarbamoyl-3-methylpyrazol-1-yl)phenoxy]piperidine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃;100%
2-chloropyrazin
14508-49-7

2-chloropyrazin

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

t-butyl 4-[(pyrazin-2-yl)oxy]piperidine-1-carboxylate
442199-08-8

t-butyl 4-[(pyrazin-2-yl)oxy]piperidine-1-carboxylate

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 2h;100%
In hexane; dimethyl sulfoxide; ethyl acetate
4-trifluoromethoxybenzyl bromide
50824-05-0

4-trifluoromethoxybenzyl bromide

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

4-[(4-trifluoromethoxy)phenyl]methoxypiperidine-1-formic acid tert-butyl ester
287952-21-0

4-[(4-trifluoromethoxy)phenyl]methoxypiperidine-1-formic acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium t-butanolate In 1,2-dimethoxyethane at 2 - 17℃; for 0.5h;
Stage #2: 4-trifluoromethoxybenzyl bromide In 1,2-dimethoxyethane at 12 - 23℃; for 3h;
100%
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In N,N-dimethyl-formamide; mineral oil for 0.5h; Cooling with ice;
Stage #2: 4-trifluoromethoxybenzyl bromide In N,N-dimethyl-formamide; mineral oil at 20℃; for 15h; Cooling with ice;
78%
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In N,N-dimethyl-formamide; mineral oil for 0.5h; Cooling with ice;
Stage #2: 4-trifluoromethoxybenzyl bromide In N,N-dimethyl-formamide; mineral oil at 20℃; for 15h;
78%
chloroacetic acid pyrrolidide
20266-00-6

chloroacetic acid pyrrolidide

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

tert-butyl 4-(2-oxo-2-(pyrrolidin-1-yl)ethoxy)piperidine-1-carboxylate
1174044-60-0

tert-butyl 4-(2-oxo-2-(pyrrolidin-1-yl)ethoxy)piperidine-1-carboxylate

Conditions
ConditionsYield
With trifluoroacetic acid; sodium hydroxide In water; toluene at 25℃;100%
4,6-dichloropyrimidine
1193-21-1

4,6-dichloropyrimidine

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

tert-butyl 4-((6-chloropyrimidin-4-yl)oxy)piperidine-1-carboxylate
442199-19-1

tert-butyl 4-((6-chloropyrimidin-4-yl)oxy)piperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In tetrahydrofuran; mineral oil at 60℃; for 1h;
Stage #2: 4,6-dichloropyrimidine In tetrahydrofuran; mineral oil at 20℃; for 2h;
100%
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In tetrahydrofuran at 60℃; for 1h; Inert atmosphere;
Stage #2: 4,6-dichloropyrimidine In tetrahydrofuran at 20℃; for 2h;
72%
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In tetrahydrofuran at 60℃; for 0.5h;
Stage #2: 4,6-dichloropyrimidine In tetrahydrofuran at 20℃;
59%
3-bromo-5-hydroxy-dipyrido[2,3-b;4',3'-d]pyrrole-9-carboxylic acid benzyl ester
1312756-30-1

3-bromo-5-hydroxy-dipyrido[2,3-b;4',3'-d]pyrrole-9-carboxylic acid benzyl ester

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

3-bromo-5-(1-tert-butoxycarbonyl-piperidin-4-yloxy)-dipyrido[2,3-b;4',3'-d]pyrrole-9-carboxylic acid benzyl ester
1312756-31-2

3-bromo-5-(1-tert-butoxycarbonyl-piperidin-4-yloxy)-dipyrido[2,3-b;4',3'-d]pyrrole-9-carboxylic acid benzyl ester

Conditions
ConditionsYield
With diethylazodicarboxylate; triphenylphosphine In tetrahydrofuran at 50℃; for 1h;100%
methyl 6-(2,6-difluoro-4-hydroxyphenyl)-5-fluoropyridine-2-carboxylate
1355011-30-1

methyl 6-(2,6-difluoro-4-hydroxyphenyl)-5-fluoropyridine-2-carboxylate

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

methyl 6-(4-((1-(tert-butoxycarbonyl)piperidin-4-yl)oxy)-2,6-difluorophenyl)-5-fluoropicolinate
1395284-49-7

methyl 6-(4-((1-(tert-butoxycarbonyl)piperidin-4-yl)oxy)-2,6-difluorophenyl)-5-fluoropicolinate

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃;100%
2-chloro-6-trifluoromethylpyridine
39890-95-4

2-chloro-6-trifluoromethylpyridine

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

tert-butyl 4-{[6-(trifluoromethyl)pyridin-2-yl]oxy}piperidine-1-carboxylate

tert-butyl 4-{[6-(trifluoromethyl)pyridin-2-yl]oxy}piperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 1h;
Stage #2: 2-chloro-6-trifluoromethylpyridine In tetrahydrofuran; mineral oil at 20℃; for 48h;
100%
propargyl bromide
106-96-7

propargyl bromide

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

tert-butyl 4-(prop-2-yn-1-yloxy)piperidine-1-carboxylate
1219827-56-1

tert-butyl 4-(prop-2-yn-1-yloxy)piperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h;
Stage #2: propargyl bromide In tetrahydrofuran; mineral oil at 25℃; for 12h;
100%
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h; Inert atmosphere;
Stage #2: propargyl bromide In tetrahydrofuran; mineral oil at 25℃; for 12h; Inert atmosphere;
100%
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h; Inert atmosphere;
Stage #2: propargyl bromide In tetrahydrofuran; mineral oil at 25℃; for 12h; Inert atmosphere;
100%
In tetrahydrofuran; toluene; mineral oil
N-[(5-chloro-2-ethylsulfonylphenyl)methyl]-4-hydroxy-3-(trifluoromethyl)benzamide

N-[(5-chloro-2-ethylsulfonylphenyl)methyl]-4-hydroxy-3-(trifluoromethyl)benzamide

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

4-[4-[(5-chloro-2-ethylsulfonylphenyl)methylcarbamoyl]-2-(trifluoromethyl)phenoxy]piperidine-1-carboxylic acid tert-butyl ester

4-[4-[(5-chloro-2-ethylsulfonylphenyl)methylcarbamoyl]-2-(trifluoromethyl)phenoxy]piperidine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20 - 50℃; for 19h;100%
2,5-dichloro-4-(trifluoromethyl)pyridine
89719-92-6

2,5-dichloro-4-(trifluoromethyl)pyridine

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

tert-butyl 4-((5-chloro-4-(trifluoromethyl)pyridin-2-yl)oxy)piperidine-1-carboxylate

tert-butyl 4-((5-chloro-4-(trifluoromethyl)pyridin-2-yl)oxy)piperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In 1,2-dimethoxyethane; mineral oil at 20℃; for 1h; Inert atmosphere;
Stage #2: 2,5-dichloro-4-(trifluoromethyl)pyridine In 1,2-dimethoxyethane; mineral oil for 2h; Inert atmosphere; Reflux;
100%
2-chloro-4-fluorobenzylbromide
45767-66-6

2-chloro-4-fluorobenzylbromide

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

tert-butyl 4-((2-chloro-4-fluorobenzyl)oxy)piperidine-1-carboxylate

tert-butyl 4-((2-chloro-4-fluorobenzyl)oxy)piperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 1h;
Stage #2: 2-chloro-4-fluorobenzylbromide With tetra-(n-butyl)ammonium iodide In N,N-dimethyl-formamide; mineral oil at 20℃; for 48h;
100%
5-bromo-2,3-dichloropyridine
97966-00-2

5-bromo-2,3-dichloropyridine

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

tert-butyl 4-((5-bromo-3-chloropyridin-2-yl)oxy)piperidine-1-carboxylate

tert-butyl 4-((5-bromo-3-chloropyridin-2-yl)oxy)piperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 1h;
Stage #2: 5-bromo-2,3-dichloropyridine In N,N-dimethyl-formamide; mineral oil at 70℃; for 16h;
100%
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In N,N-dimethyl acetamide at 20℃; for 1h;
Stage #2: 5-bromo-2,3-dichloropyridine In N,N-dimethyl acetamide at 80℃; Inert atmosphere;
57%
methyl 4-hydroxy-2-methoxybenzoate
28478-46-8

methyl 4-hydroxy-2-methoxybenzoate

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

4-(N-t-Butoxycarbonyl-4-piperidinyloxy)-2-methoxybenzoic acid methyl ester
162045-37-6

4-(N-t-Butoxycarbonyl-4-piperidinyloxy)-2-methoxybenzoic acid methyl ester

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 40℃; for 2h; Inert atmosphere; Sonication;100%
2-hydroxyl nicotinic acid ethyl ester
27805-12-5

2-hydroxyl nicotinic acid ethyl ester

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

C18H26N2O5

C18H26N2O5

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 4h; Mitsunobu Displacement;100%
6-methoxypyridine-3-ol
51834-97-0

6-methoxypyridine-3-ol

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

tert-butyl 4-((6-methoxypyridin-3-yl)oxy)piperidine-1-carboxylate

tert-butyl 4-((6-methoxypyridin-3-yl)oxy)piperidine-1-carboxylate

Conditions
ConditionsYield
With triphenylphosphine In tetrahydrofuran at 20℃; for 9h; Inert atmosphere;100%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 40℃; for 1h; Inert atmosphere;
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 40℃; for 1h; Inert atmosphere;
methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate
141699-59-4

1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate

Conditions
ConditionsYield
With triethylamine In dichloromethane; ethyl acetate100%
With triethylamine In dichloromethane; ethyl acetate100%
With triethylamine In dichloromethane; ethyl acetate100%

109384-19-2Downstream Products

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