1093879-46-9

Usage

Uses

Used in Pharmaceutical Industry:
2-(6-bromopyridin-2-yl)acetic acid is used as a key intermediate in the synthesis of pyrimidine derivatives, which are known as RORγ modulators. These modulators play a crucial role in regulating the RORγ protein, a potential target for treating various inflammatory and autoimmune diseases. By modulating RORγ, these pyrimidine derivatives can help in the development of novel therapeutics for conditions such as rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2-(6-bromopyridin-2-yl)acetic acid can be utilized as a building block for the creation of more complex molecules with diverse applications. Its unique structural features make it a valuable component in the design and synthesis of new compounds with potential uses in various industries, including pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 955369-63-8 (6-bromo-pyridin-2-yl)-acetic acid ethyl ester 
• 1387560-41-9 2-(6-Bromo-pyridin-2-yl)-malonic acid diethyl ester 
• 5315-25-3 2-bromo-6-methylpyridine 

Relevant academic research and scientific papers

SHMT INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Synthesis of (-)-Cytisine Using a 6- endo aza-Michael Addition

An asymmetric synthesis of (-)-cytisine has been achieved. The piperidine C-ring was formed using a stereodivergent intramolecular 6-endo aza-Michael addition. The B-ring was established by intramolecular pyridine N-alkylation. The absolute stereochemistry was established by an Evans acyl oxazolidinone enolate alkylation reaction that proceeded with an unexpected stereochemical outcome due to participation of the pyridine nitrogen lone pair.

COMPOUNDS FOR TREATMENT OF IMMUNE AND INFLAMMATORY DISORDERS

Compounds, methods of use, and processes for making inhibitors of complement Factor D are provided comprising Formula I, I" and I'" or a pharmaceutically acceptable salt or composition thereof. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein reduces the excessive activation of complement.

Novel Heterocyclic Derivatives and Their Use in the Treatment of Neurological Disorders

The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.