109389-10-8

Basic information

• Product Name: (2R,3S)-3-Amino-4-phenyl-butane-1,2-diol
• Synonyms: (2R,3S)-3-Amino-4-phenyl-butane-1,2-diol
• CAS NO: 109389-10-8
• Molecular Weight: 181.235
• Mol File: 109389-10-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,3S)-3-Amino-4-phenyl-butane-1,2-diol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S)-3-Amino-4-phenyl-butane-1,2-diol(109389-10-8)
• EPA Substance Registry System: (2R,3S)-3-Amino-4-phenyl-butane-1,2-diol(109389-10-8)

Safety Data

• Hazardous Substances Data: 109389-10-8(Hazardous Substances Data)

Upstream product

• 111138-83-1 N,N-dibenzyl-L-phenylalanine benzyl ester 
• 189562-37-6 (3S)-3-(N,N-dibenzyl)amino-1-hydroxy-1-methylthio-2-oxo-4-phenylbutane 
• 184537-69-7 (3S)-3-(N,N-dibenzyl)amino-1-methylsulfinyl-2-oxo-4-phenylbutane 
• 200616-26-8 (2R,3S)-3-dibenzylamino-5-phenylbutane-1,2-diol 

Downstream Products

• 98760-08-8 (2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane 
• 200616-28-0 Acetic acid (1R,2S)-1-bromomethyl-2-tert-butoxycarbonylamino-3-phenyl-propyl ester 
• 99113-35-6 ((1S,2R)-1-benzyl-2,3-dihydroxypropyl)carbamic acid tert-butyl ester 

Relevant articles and documents

An efficient synthesis of N-protected threo (2R,3S)-3-amino-1,2-epoxy phenylbutane

A precise and versatile method was developed for the synthesis of threo amino epoxide derivatives, which are useful intermediates for protease inhibitors. It involves the diastereoselective reduction of the carbonyl group of γ-N,N-dibenzyl amino α-hydroxy β-keto sulfide prepared from an amino acid, and its subsequent stereospecific conversion to an amino epoxide via acetoxy halogenation in high yield.