109389-30-2

Basic information

• Product Name: DMT-DU AMIDITE 0.25G, AB, SINGLE
• Synonyms: DMT-DU AMIDITE 0.25G, AB, SINGLE;deoxyuridine-ce phosphoramidite*for cyclone;DMT-DU AMIDITE 0.25G 89 SINGLE;DMT-DURIDINE CYANOETHYL PHOSPHORAMIDITE);N-blocked-5'-O-DMT 3'-CED deoxyuridine phosphoramidite;Uridine, 5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-deoxy-, 3'-[2-cyanoethyl bis(1-Methylethyl)phosphoraMidite];5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite];5'-O-DMT-2'-deoxyuridine-3'-CE-Phosphoramidite
• CAS NO: 109389-30-2
• Molecular Formula: C₃₉H₄₇N₄O₈P
• Molecular Weight: 730.786241
• Mol File: 109389-30-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• PKA: 9.39±0.10(Predicted)
• CAS DataBase Reference: DMT-DU AMIDITE 0.25G, AB, SINGLE(CAS DataBase Reference)
• NIST Chemistry Reference: DMT-DU AMIDITE 0.25G, AB, SINGLE(109389-30-2)
• EPA Substance Registry System: DMT-DU AMIDITE 0.25G, AB, SINGLE(109389-30-2)

Safety Data

• Hazardous Substances Data: 109389-30-2(Hazardous Substances Data)

Usage

Uses

Dmt-Du Amidite is used as a reactant in the synthesis of nucleotide related substances.

Upstream product

• 23669-79-6 DMT-dU 
• 102691-36-1 N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite 

Downstream Products

• 349490-28-4 C₄₉H₆₂N₅O₁₄PSi 
• 349490-33-1 C₄₉H₆₂N₅O₁₅PSi 
• 349490-22-8 C₄₉H₆₀N₅O₁₄PSi 
• 349490-15-9 C₄₉H₅₂N₅O₁₄PSe 
• 349490-16-0 C₄₉H₅₂N₅O₁₄PSe 
• 770700-22-6 phosphoric acid 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 3-hydroxy-5-(5-methyl-2,4-dioxo-5-phenylselanyl-tetrahydro-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 
• 698345-07-2 phosphoric acid 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 3-hydroxy-5-(5-methyl-2,4-dioxo-5-phenylselanyl-tetrahydro-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 

Relevant articles and documents

Studies on the synthesis of neamine-dinucleosides and neamine-PNA conjugates and their interaction with RNA

Two types of neamine derivatives, neamine-dinucleotide conjugates 8a-g and neamine-PNA conjugates 12a-c and 14a-d, were synthesized. Compound 8a-g were synthesized by the condensation of azido-neamine with dinucleotide-5′-carboxylic acids, followed by reduction and deprotection. Compound 12a-c and 14a-d were synthesized by the similar strategy. The binding affinities of conjugates 8a-g, 12a-c, and 14a-d towards 16S RNA, 18S RNA, and TAR RNA were evaluated by SPR. It indicates that conjugates 12a-c and 14a-d interact with 16S, 18S RNA at the same level as that of neamine, 14a and 14d show about twofold binding affinities to TAR RNA compared to that of neamine. However, the neamine-dinucleotide conjugates 8a-g exhibit very weak binding affinities to 16S, 18S, and TAR RNA, computer modelling results that negative-negative electrostatic repulsion of phosphate group in compound 8a-g and RNA leads to a sharp decrease of the binding affinities compared with that of neamine, neamine-nucleoside and neamine-PNA conjugates.