1093972-18-9Relevant articles and documents
Chroman-3-amides as potent Rho kinase inhibitors
Chen, Yen Ting,Bannister, Thomas D.,Weiser, Amiee,Griffin, Evelyn,Lin, Li,Ruiz, Claudia,Cameron, Michael D.,Schuerer, Stephan,Duckett, Derek,Schroeter, Thomas,LoGrasso, Philip,Feng, Yangbo
scheme or table, p. 6406 - 6409 (2009/10/01)
Inhibition of Rho kinase (ROCK) is an attractive strategy for the treatment of diseases such as hypertension, glaucoma, and cancer. Here we report chroman-3-amides as highly potent ROCK inhibitors with sufficient kinase selectivity, excellent cell activit