1093987-01-9

Upstream product

• 117186-74-0 N-(2-benzoylphenyl)-L-prolinamide 

Downstream Products

• 1093987-04-2 (5R/S,11aS)-5-phenyl-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-11-one 
• 30651-46-8 (2-acetamidophenyl)(phenyl)methyl acetate 

Relevant academic research and scientific papers

Enantiospecific synthesis of 5-phenylpyrrolo[2,1-c][1,4]benzodiazepines

Enantiomerically pure 5-phenylpyrrolo[2,1-c][1,4]benzodiazepines were synthesized starting from 2-aminobenzophenones and 2-amino-4-methoxyxanthone, using l-proline as a chiral building block.

Synthesis of 5-arylpyrrolo[2,1-c][1,4]benzodiazepines under mild cyclodehydration conditions

The efficiency of a cyclodehydration reaction leading to benzodiazepinones is markedly improved by N-methylation of the amide link connecting the nucleophile and the electrophile, which is attributed to its favouring both the more reactive E-rotamer and the exit of the leaving group.