1094-63-9

Usage

Chemical structure

1,3-dimethyl-8-(4-nitrophenyl)-3,7-dihydro-1H-purine-2,6-dione

Occurrence

Commonly found in coffee, tea, and energy drinks

Functionality

Central nervous system stimulant

Additional effects

Acts as a mild diuretic

Benefits

Improves mental alertness, reduces fatigue, enhances physical performance

Medical uses

Treatment of headaches, migraines, and respiratory disorders

Adverse effects

Insomnia, restlessness, increased heart rate (with excessive consumption)

Upstream product

• 76473-17-1 6-amino-1,3-dimethyl-5-<(p-nitrobenzylidene)amino>uracil 
• 5440-00-6 4,5-Diamino-1,3-dimethyluracil 
• 555-16-8 4-nitrobenzaldehdye 
• 147623-06-1 1,3-Dimethyl-8-(4-nitro-phenyl)-6-phenyl-1,9-dihydro-pyrimido[4,5-b][1,4]diazepine-2,4-dione 
• 220419-53-4 6-amino-1,3-dimethyl-5-(4-nitrobenzylidene)aminouracil 
• 249929-77-9 C₁₃H₁₃N₅O₅ 
• 62-23-7 4-nitro-benzoic acid 
• 58-55-9 theophylline 
• 56075-39-9 1-(methylsulfonyl)-2-(4-nitrophenyl)diazene 
• 147622-97-7 4-nitro-β-(5-amino-6-imino-1,3-dimethyluracil)chalcone 

Downstream Products

• 85872-66-8 8-(p-aminophenyl)theophylline 

Relevant academic research and scientific papers

Smooth Metal-Free Photoinduced Preparation of Valuable 8-Arylxanthines

A set of 8-arylxanthines was prepared under metal-free conditions and in aqueous solvents from arylazo sulfones and caffeine or theophylline. Notably, the process took place by simply exposing the reaction vessel to visible or solar light, and unreacted xanthine could be easily recovered during the purification step.

Exploration of polystyrene-supported 2-isobutoxy-1-isobutoxycarbonyl-1,2- dihydroquinoline (PS-IIDQ) as new coupling agent for the synthesis of 8-substituted xanthine derivatives

Polystyrene-supported 2-isobutoxy-1-isobutoxycarbonyl-1,2-dihydroquinoline (PS-IIDQ), a polymer supported covalent coupling reagent, was successfully employed for the first time in the synthesis of 8-substituted xanthine derivatives. PS-IIDQ was observed

A mild method for the preparation of 8-substituted xanthines from 5,6- diaminouracils

The Schiff base derivatives (3), prepared from the respective 5,6- diaminouracil (1) and aldehydes can be mildly oxidatively cyclized with m- CPBA in MeCN to afford C-8 substituted xanthines (6).

REACTIONS OF 5,6-DIAMINO-1,3-DIMETYLURACIL WITH HALOGEN DERIVATIVES OF CHALCONES

The reaction of 5,6-diamino-1,3-dimethyluracil with 1,3-diaryl-2,3-dibromopropan-1-ones gave β-(5-amino-6-imino-1,3-dimethyluracil)chalcones, and conditions for their cyclocondensation to pyrimidinodiazepines were found.For substantiation of the reaction mechanism, the reaction of the diamine with other halogen derivatives of chalcones was studied.The IR, UV, and mass spectra of the synthesized compounds and their condensation products are discussed.

1,3-Dialkyl-8-(p-sulfophenyl)xanthines: Potent Water-Soluble Antagonistst for A1- and A2-Adenosine Receptors

A series of 8-(substituted phenyl) derivatives of Theophylline and other 1,3-dialkylxanthines were evaluated for potency and selectivity as antagonists at A1- and A2-adenosine receptors in brain tissue.Theophylline has a similar pote