1094-77-5

Basic information

• Product Name: 2-(2-benzylpyridin-1(2H)-yl)-1-phenylethanone
• CAS NO: 1094-77-5
• Molecular Formula: Br*C₂₀H₁₈NO
• Molecular Weight: 289.371
• Mol File: 1094-77-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 465.2°C at 760 mmHg
• Flash Point: 182.4°C
• Density: 1.115g/cm³
• Vapor Pressure: 7.84E-09mmHg at 25°C
• Refractive Index: 1.604
• CAS DataBase Reference: 2-(2-benzylpyridin-1(2H)-yl)-1-phenylethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-benzylpyridin-1(2H)-yl)-1-phenylethanone(1094-77-5)
• EPA Substance Registry System: 2-(2-benzylpyridin-1(2H)-yl)-1-phenylethanone(1094-77-5)

Safety Data

• Hazardous Substances Data: 1094-77-5(Hazardous Substances Data)

Usage

General Description

"2-(2-benzylpyridin-1(2H)-yl)-1-phenylethanone" is a chemical compound with the molecular formula C22H19NO. It is a yellow, crystalline powder that is insoluble in water but soluble in organic solvents. 2-(2-benzylpyridin-1(2H)-yl)-1-phenylethanone is used in pharmaceutical research as a building block for the synthesis of various biologically active molecules. It is also studied for its potential pharmacological properties, particularly its role in the treatment of neurological disorders and as a potential anti-inflammatory agent. Additionally, its unique structure and properties make it a valuable tool for chemical and medicinal chemistry research.

Upstream product

• 101-82-6 2-Benzylpyridine 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 131354-23-9 Phenyl-(1-phenyl-[1,3]azaphospholo[1,5-a]pyridin-3-yl)-methanone 
• 1035-41-2 1,2-diphenylindolizine 

Relevant articles and documents

Enantioselective Synthesis of 3-Allylindolizines via Sequential Rh-Catalyzed Asymmetric Allylation and Tschitschibabin Reaction

The first highly regio- and enantioselective synthesis of 3-allylindolizines has been developed by the sequential Rh-catalyzed asymmetric allylation and Tschitschibabin reaction. Above the 20:1 branch/linear ratio, up to a 96% yield and 99% ee could be obtained with the help of tert-butyl-substituted chiral bisoxazolinephosphine ligand. In situ generated highly nucleophilic 2-alkylpyridinium ylides are utilized to undergo the asymmetric alkylation reaction before cyclization.

2-Phosphaindolizines

Pyridinium bromides 3 prepared by alkylation of 2-methyl-, 2-ethyl-, and 2-benzylpyridines 1 with methyl bromides 2 bearing an electron-withdrawing group (COPh, CN, CO2Et, C6H4NO2) are condensed with PCl3 in the presence of Et3N to give 2-phosphaindolizin