1094209-98-9Relevant academic research and scientific papers
Antimycobacterial and H1-antihistaminic activity of 2-substituted piperidine derivatives
Weis, Robert,Schweiger, Klaus,Faist, Johanna,Rajkovic, Erich,Kungl, Andreas J.,Fabian, Walter M.F.,Schunack, Walter,Seebacher, Werner
experimental part, p. 10326 - 10331 (2009/05/11)
2-Substituted derivatives of the antihistaminic agents Bamipine, Diphenylpyraline and of their 1-phenyl analogues were tested for their antimycobacterial and H1-antagonistic activities. They are strong H1-receptor antagonists and also inhibit the growth of mycobacterials with a maximum MIC of 6.25 μg/mL against Mycobacterium tuberculosis H37Rv. H1-receptor antagonistic potency was slightly decreased by substitution in ring position 2 and distinctly diminished by N-aryl substitution. The antimycobacterial potency of Diphenylpyraline was in general increased by substitution in ring position 2, whereas only a few Bamipine derivatives showed markedly improved activity. A correlation between the two activities was not detected for those compounds.
