1094223-48-9

Basic information

• Product Name: [1-(6-Chloropyridazin-3-yl)piperidin-4-yl]methanol
• Synonyms: [1-(6-Chloropyridazin-3-yl)piperidin-4-yl]methanol;[1-(6-Chloro-3-pyridazinyl)-4-piperidyl]Methanol
• CAS NO: 1094223-48-9
• Molecular Formula: C10H14ClN3O
• Molecular Weight: 227.69066
• Mol File: 1094223-48-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 455.7±30.0 °C(Predicted)
• Appearance: /
• Density: 1.274±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 14.94±0.10(Predicted)
• CAS DataBase Reference: [1-(6-Chloropyridazin-3-yl)piperidin-4-yl]methanol(CAS DataBase Reference)
• NIST Chemistry Reference: [1-(6-Chloropyridazin-3-yl)piperidin-4-yl]methanol(1094223-48-9)
• EPA Substance Registry System: [1-(6-Chloropyridazin-3-yl)piperidin-4-yl]methanol(1094223-48-9)

Safety Data

• Hazardous Substances Data: 1094223-48-9(Hazardous Substances Data)

Usage

General Description

[1-(6-Chloropyridazin-3-yl)piperidin-4-yl]methanol is a chemical compound containing a piperidine ring and a chloropyridazine group. It has the molecular formula C12H16ClN3O and a molecular weight of 251.73 g/mol. [1-(6-Chloropyridazin-3-yl)piperidin-4-yl]methanol is commonly used in organic synthesis and pharmaceutical research as a building block for the production of various drugs and bioactive molecules. It is important for the development of new medications due to its ability to interact with biological systems and potentially exhibit therapeutic effects. Additionally, [1-(6-Chloropyridazin-3-yl)piperidin-4-yl]methanol may have applications in the field of medicinal chemistry and drug discovery.

Upstream product

• 6457-49-4 4-piperidinemethanol 
• 141-30-0 3,6-dichlorpyridazine 

Downstream Products

• 1588959-00-5 9-((1r,4r)-4-methylcyclohexyl)-N-(6-(4-((methylsulfonyl)methyl)-piperidin-1-yl)pyridazin-3-yl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-amine 

Relevant articles and documents

Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3

We describe the structural optimization of a lead compound 1 that exhibits dual inhibitory activities against FLT3 and CDK4. A series of pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidine derivatives was synthesized, and SAR analysis, using cell-based assays, led to the discovery of 28 (AMG 925), a potent and orally bioavailable dual inhibitor of CDK4 and FLT3, including many FLT3 mutants reported to date. Compound 28 inhibits the proliferation of a panel of human tumor cell lines including Colo205 (Rb +) and U937 (FLT3WT) and induced cell death in MOLM13 (FLT3ITD) and even in MOLM13 (FLT3ITD, D835Y), which exhibits resistance to a number of FLT3 inhibitors currently under clinical development. At well-tolerated doses, compound 28 leads to significant growth inhibition of MOLM13 xenografts in nude mice, and the activity correlates with inhibition of STAT5 and Rb phosphorylation.