1094554-37-6 Usage
Chemical structure
A complex structure consisting of a piperazine ring, a methyl group, and a benzyl group with a fluorine and nitro substituent.
Molecular weight
Approximately 230.23 g/mol
Functional groups
Piperazine ring, methyl group, benzyl group, fluorine atom, and nitro group
Appearance
It is likely a solid or crystalline substance, although the exact appearance is not provided in the material.
Pharmaceutical industry application
Used as a potential drug candidate for the treatment of various diseases.
Biological activity
Its unique structure and functional groups give it potential biological activity and therapeutic effects.
Medicinal chemistry research
It is a valuable tool in medicinal chemistry research and drug development.
Solubility
The solubility of this compound is not provided in the material, but it may vary depending on the solvent used.
Stability
The stability of this compound under different conditions is not provided in the material, but it may be influenced by factors such as temperature, light, and humidity.
Synthesis
The synthesis method for this compound is not provided in the material, but it likely involves the formation of the piperazine ring, attachment of the methyl group, and subsequent functionalization of the benzyl group with fluorine and nitro substituents.
Purity
The purity of this compound is not provided in the material, but it is an important factor in its effectiveness and safety as a drug candidate.
Toxicity
The toxicity of this compound is not provided in the material, but it is a critical factor to consider in drug development and safety assessments.
Patent status
The patent status of this compound is not provided in the material, but it may be protected by intellectual property rights depending on its development and commercialization.
Check Digit Verification of cas no
The CAS Registry Mumber 1094554-37-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,9,4,5,5 and 4 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1094554-37:
(9*1)+(8*0)+(7*9)+(6*4)+(5*5)+(4*5)+(3*4)+(2*3)+(1*7)=166
166 % 10 = 6
So 1094554-37-6 is a valid CAS Registry Number.
1094554-37-6Relevant articles and documents
N-aryl-2-aminobenzimidazoles: Novel, efficacious, antimalarial lead compounds
Ramachandran, Sreekanth,Hameed P., Shahul,Srivastava, Abhishek,Shanbhag, Gajanan,Morayya, Sapna,Rautela, Nikhil,Awasthy, Disha,Kavanagh, Stefan,Bharath, Sowmya,Reddy, Jitendar,Panduga, Vijender,Prabhakar,Saralaya, Ramanatha,Nanduri, Robert,Raichurkar, Anandkumar,Menasinakai, Sreenivasaiah,Achar, Vijayashree,Jiménez-Díaz, María Belén,Martínez, María Santos,Angulo-Barturen, I?igo,Ferrer, Santiago,Sanz, Laura María,Gamo, Francisco Javier,Duffy, Sandra,Avery, Vicky M.,Waterson, David,Lee, Marcus C. S.,Coburn-Flynn, Olivia,Fidock, David A.,Iyer, Pravin S.,Narayanan, Shridhar,Hosagrahara, Vinayak,Sambandamurthy, Vasan K.
supporting information, p. 6642 - 6652 (2014/10/15)
From the phenotypic screening of the AstraZeneca corporate compound collection, N-aryl-2-aminobenzimidazoles have emerged as novel hits against the asexual blood stage of Plasmodium falciparum (Pf). Medicinal chemistry optimization of the potency against Pf and ADME properties resulted in the identification of 12 as a lead molecule. Compound 12 was efficacious in the P. berghei (Pb) model of malaria. This compound displayed an excellent pharmacokinetic profile with a long half-life (19 h) in rat blood. This profile led to an extended survival of animals for over 30 days following a dose of 50 mg/kg in the Pb malaria model. Compound 12 retains its potency against a panel of Pf isolates with known mechanisms of resistance. The fast killing observed in the in vitro parasite reduction ratio (PRR) assay coupled with the extended survival highlights the promise of this novel chemical class for the treatment of malaria.
