109461-69-0

Usage

Uses

Used in Pharmaceutical Industry:
2-[4-(Ethoxycarbonyl)phenyl]-6-methyl-imidazo[1,2-a]pyridine is used as a chemical intermediate for the preparation of Zolpidem metabolites. It is crucial in the synthesis process, enabling the production of these metabolites that have significant applications in the pharmaceutical field.

InChI:InChI=1/C17H16N2O2/c1-3-21-17(20)14-7-5-13(6-8-14)15-11-19-10-12(2)4-9-16(19)18-15/h4-11H,3H2,1-2H3

Upstream product

• 64-17-5 ethanol 
• 201230-82-2 carbon monoxide 
• 1603-41-4 (5-methyl-pyridin-2-yl)amine 
• 81590-55-8 ethyl 4-(2-bromoacetyl)benzoate 

Downstream Products

• 917252-83-6 ethyl 4-[(3-tert-butoxycarbonylmethyl-6-methyl)imidazo[1,2-a]pyridin-2-yl]benzoate 

Relevant academic research and scientific papers

Major metabolites of Zolpidem: Expeditious synthesis and mass spectra

An expeditious route to the two major metabolites of Zolpidem - and readily applicable to the synthesis of the drug - was established via a cyclization reaction between a 2-aminopyridine and a suitable α-bromoacetophenone. The structures of the target compounds were confirmed from a 2D 1H- 15N NMR correlation. Their mass spectra contribute to a reliable toxicological identification of the drug in the case of drug-facilitated crimes.

Benzoheterocyclic derivatives

A benzoheterocyclic derivative of the following formula [1]: and pharmaceutically acceptable salts thereof, which show excellent anti-vasopressin activity, vasopressin agonistic activity and oxytocin antagonistic activity, and are useful as a vasopressin antagonist, vasopressin agonist or oxytocin antagonist.

3-(acylaminomethyl)imidazo[1,2-a]pyridine derivatives and pharmaceutical compositions

A compound which is a 3-(acylaminomethyl)imidazo[1,2-a]pyridine derivative of formula (I) STR1 or a pharmacologically acceptable acid addition salt is useful in therapy.