1094618-82-2Relevant academic research and scientific papers
Synthesis and biological evaluation of new tacrine analogues under microwave irradiation
Alshareef, Hossa Fahad,Mohamed, Heba Abd El Hady,Salaheldin, Abdellatif Mohamed
, p. 732 - 738 (2017/08/09)
Efficient routes to various kinds of heterocycles incorporating the p-halophenyl moiety have been synthesized. Different pyrrole derivatives have been synthesized, as well, by Thorpe–Ziegler cyclization. Therefore, we synthesized different analogues of tacrine by Friedl?nder reaction of o-amino nitriles (pyrazolo, furano and pyrrolo) with different cycloalkanones. The use of microwave irradiation leads to shorter production times and high product conversion. These synthesized compounds were biologically evaluated by Ellman’s test on acetylcholinesterase inhibition.
Facile synthesis of novel tacrine analogues
Hu, Huanan,Zhang, Anjiang,Ding, Lisheng
experimental part, p. 562 - 564 (2010/02/28)
The synthesis of highly potent and selective acetylcholinesterase inhibitors, tacrine analogues with the structure of fused 4-aminoquinolines and 4-aminopyridines, has been accomplished by direct cyclocondensation of 1-aryl-4- cyano-5-aminopyrazoles with
Synthesis of tacrine analogs derived from N-Aryl-5-amino-4-cyanopyrazoles
Rodrigues, Ligia M.,Francisco, Carla S.,Oliveira-Campos, Ana M. F.,Salaheldin, Abdellatif M.
experimental part, p. 4369 - 4378 (2009/04/11)
Synthesis of 11 tacrine analogs derived from N-aryl-5-amino-4- cyanopyrazoles, by a Friedlander type reaction, is described. Their structures were confirmed by 1H and 13C NMR spectroscopy, elemental analysis, and/or mass spectrometry. Copyright Taylor & Francis Group, LLC.
