1094619-25-6

Basic information

• Product Name: (2S)-1-phenylsulfonylpyrrolidine-2-carboxylic acid ethyl ester
• Synonyms: ethyl (2S)-1-phenylsulfonylpyrrolidine-2-carboxylate;ethyl 1-(phenylsulfonyl)prolinate;(2S)-1-phenylsulfonyl-2-pyrrolidinecarboxylic acid ethyl ester;(2S)-1-phenylsulfonylpyrrolidine-2-carboxylic acid ethyl ester;1-Benzenesulfonyl-pyrrolidine-2-carboxylic acid ethyl ester
• CAS NO: 1094619-25-6
• Molecular Formula: C13H17NO4S
• Molecular Weight: 283.35
• Mol File: 1094619-25-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 408.2±55.0 °C(Predicted)
• Appearance: /
• Density: 1.281±0.06 g/cm3(Predicted)
• PKA: -6.86±0.40(Predicted)
• CAS DataBase Reference: (2S)-1-phenylsulfonylpyrrolidine-2-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-1-phenylsulfonylpyrrolidine-2-carboxylic acid ethyl ester(1094619-25-6)
• EPA Substance Registry System: (2S)-1-phenylsulfonylpyrrolidine-2-carboxylic acid ethyl ester(1094619-25-6)

Safety Data

• Hazardous Substances Data: 1094619-25-6(Hazardous Substances Data)

Usage

General Description

(2S)-1-phenylsulfonylpyrrolidine-2-carboxylic acid ethyl ester is a chemical compound with the chemical formula C14H19NO4S. It is a derivative of pyrrolidine, containing a sulfonyl group and an ethyl ester group. (2S)-1-phenylsulfonylpyrrolidine-2-carboxylic acid ethyl ester is used in organic synthesis as a reagent for the preparation of various organic compounds. It is also utilized in pharmaceutical research as a building block for the synthesis of potential drug candidates. Additionally, it may have potential applications in medicinal chemistry and drug development due to its unique structural properties. Overall, (2S)-1-phenylsulfonylpyrrolidine-2-carboxylic acid ethyl ester plays a significant role in the advancement of chemical and pharmaceutical industries.

Upstream product

• 98-09-9 benzenesulfonyl chloride 
• 5817-26-5 ethyl (2S)-pyrrolidine-2-carboxylate 

Downstream Products

• 1375314-03-6 1,1,3,3-tetramethyl-1,3-bis(N-methyl-N'-phenylsulfonyl-(S)-prolinamidomethyl)-1,3-disiloxane 

Relevant articles and documents

Pentacoordinated chlorosilanes with C,O-chelate ligands derived from N-methyl-N’-organosulfonyl-prolinamides

The reaction of amides RSO2-Pro-NHMe with ClCH2SiMe2Cl in the presence of (Me3Si)2NH gave pentacoordinatedchlorosilanes RSO2-Pro-N(Me)CH2SiMe2Cl with an organosulfonyl group (R = Me, Ph, 4-ClC6H4, 4-BrC6H4, 4-MeC6H4, and 4-O2NC6H4) attached to the proline nitrogen atom. An alternative method for the preparation of these compounds comprises the cyclosilylmethylation of proline methylamide by dimethylchloromethylchlorosilane to give the previously unreported heterocyclic 2-sila-5-piperazinone system in the first step. The bicyclic silacyclane synthesized is 2-sila-5-piperazinone condensed with a proline residue. The action of sulfonyl chlorides RSO2Cl leads to cleavage of the sila ring Si–N bond to give the desired chlorosilanes. The hydrolysis of these products, depending on the reaction conditions, gives either silyloxonium chlorides [RSO2-Pro-N(Me)CH2SiMe2OH2]Cl or disiloxanes [RSO2-Pro-N(Me)CH2SiMe2]2O. X-ray diffraction structural analysis showed that the silicon atom in the chlorides and silyloxonium chlorides is pentacoordinated due to an intramolecular O→Si bond and has distorted trigonal-bipyrimidal configuration.29Si NMR spectroscopy showed that the disiloxanes and bicyclic sila-5-piperazinone have a tetracoordinated silicon atom.