109462-20-6

Basic information

• Product Name: 3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester
• Synonyms: 3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester;3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]Pentanedioic acid 1-methyl ester;3-((t-butyldimethylsilyl)oxy)-5-methoxy-5-oxopentanoic acid;3-(tert-Butyl(dimethyl)silyl)oxy-5-methoxy-5-oxo-pentanoic acid
• CAS NO: 109462-20-6
• Molecular Formula: C₁₂H₂₄O₅Si
• Molecular Weight: 248.3483
• Mol File: 109462-20-6.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester(109462-20-6)
• EPA Substance Registry System: 3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester(109462-20-6)

Safety Data

• Hazardous Substances Data: 109462-20-6(Hazardous Substances Data)

Usage

General Description

3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester, also known as DMDO-Pentanedioic acid monomethyl ester, is a chemical compound with the molecular formula C10H20O6Si. It is a monomethyl ester derivative of pentanedioic acid, containing a silyl functional group. 3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester is often used as a reagent in organic synthesis and as a building block for the synthesis of other organic compounds. It is a clear, colorless liquid with a molecular weight of 260.35 g/mol and is considered to be stable under normal conditions. DMDO-Pentanedioic acid monomethyl ester is also known for its potential use as an intermediate in the production of pharmaceuticals, agrochemicals, and other specialty chemicals.

Upstream product

• 91424-40-7 3-(tert-butyldimethylsilyloxy)glutaric anhydride 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 91424-39-4 3-[[(1,1-Dimethylethyl)dimethylsilyl]-oxy]pentanedioic acid,diethyl ester 
• 32328-03-3 diethyl 3-hydroxyglutarate 
• 109462-19-3 Monomethyl 3-Hydroxypentanedioic Acid 
• 112904-68-4 3-(tert-butyl-dimethyl-silanyloxy)-pentanedioic acid dimethyl ester 
• 91465-61-1 (+/-)-methyl tert-butyldimethylsilyl 3-<(tert-butyldimethylsilyl)oxy>pentanedioate 
• 67-56-1 methanol 

Downstream Products

• 130075-10-4 methyl 4-<1-(benzyyloxy)-2-oxo-4-azetidinyl>α-diazo-β-ketobutyrate 
• 131352-67-5 ((1R,5R)-3-Oxo-6-phenylcarbamoyl-2,7-dioxa-6-aza-bicyclo[3.2.1]oct-1-yl)-acetic acid methyl ester 
• 131352-64-2 (Z)-6-Benzyloxycarbamoyl-3-oxo-hex-4-enoic acid methyl ester 
• 130075-12-6 β-<(tert-butyldimethylsilyl)oxy>-δ-hydroxypimelic acid, N-(benzyloxy)amide monomethyl ester 
• 133374-67-1 methyl 4-<1-(benzyloxy)-2-oxo-4-azetidinyl>-β-<(tert-butyldimethylsilyl)oxy>butyrate 
• 131352-56-2 β-<(tert-butyldimethylsilyl)oxy>-δ-hydroxypimelic acid, methyl benzyl diester 
• 131352-62-0 methyl 4-<1-(benzyloxy)-2-oxo-4-azetidinyl>-β-hydroxybutyrate 
• 130075-13-7 methyl 4-<1-(benzyloxy)-2-oxo-4-azetidinyl>-β-ketobutyrate 
• 195510-91-9 (R)-3-(tert-butyldimethylsilanyloxy)-4-{3-[3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)ureido]benzyloxycarbonylamino}butyric acid methyl ester 
• 130075-11-5 β-<(tert-butyldimethylsilyl)oxy>-δ-oxopimelic acid, methyl benzyl diester 

Relevant articles and documents

A process for preparing rosuvastatin calcium intermediate method

The invention relates to a method for preparing a rosuvastatin calcium intermediate, in particular to a preparation method for a compound shown in the formula 3. According to the method, ethyl (R)-(-)-4-cyano-3-hydroxybutyate is mainly used as an initial material for performing a hydroxyl protecting reaction and then the esterification reaction is performed, so that the target product is prepared. The preparation method provided by the invention is simple in operation, less in reaction steps and greatly reduces production cost; moreover, the rosuvastatin calcium intermediate is high in purity and yield, and stable in quality and has a wide prospect in the industrial application.(shown in the specification).

PROCESS AND INTERMEDIATES FOR THE SELECTIVE SYNTHESIS OF FLUVASTATIN

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3-Hydroxyglutarate and β,γ-Epoxy Esters as Substrates for Pig Liver Esterase (PLE) and α-Chymotrypsin

The pH dependence of the α-chymotrypsin-catalyzed hydrolysis of dimethyl 3-hydroxyglutarate (3) has been studied.The e.e. was determined by HPLC analysis of diastereoisomeric camphanoic-acid derivatives.Kinetic resolution of the β,γ-epoxy esters 10 and 24 by pig liver esterase has been shown to provide an alternative access to chiral β-hydroxy esters and acids of high optical purity.By this latter method, the unnatural enantiomer of γ-amino-β-hydroxybutyric acid (GABOB) has been sinthesized.Finally, dimethyl meso-3,4-epoxyadipate (19) was hydrolyzed by pig liver esterase with almost 100 percent selectivity.