109463-77-6

Basic information

• Product Name: (1R,2R)-2-Methyl-2-(1-methyl-1H-indol-2-yl)-cyclohexanecarbaldehyde
• Synonyms: (1R,2R)-2-Methyl-2-(1-methyl-1H-indol-2-yl)-cyclohexanecarbaldehyde
• CAS NO: 109463-77-6
• Molecular Weight: 255.36
• Mol File: 109463-77-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R,2R)-2-Methyl-2-(1-methyl-1H-indol-2-yl)-cyclohexanecarbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R)-2-Methyl-2-(1-methyl-1H-indol-2-yl)-cyclohexanecarbaldehyde(109463-77-6)
• EPA Substance Registry System: (1R,2R)-2-Methyl-2-(1-methyl-1H-indol-2-yl)-cyclohexanecarbaldehyde(109463-77-6)

Safety Data

• Hazardous Substances Data: 109463-77-6(Hazardous Substances Data)

Upstream product

• 95-53-4 o-toluidine 
• 109463-76-5 2-[(1R,2R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-1-methyl-cyclohexyl]-1-methyl-1H-indole 
• 109463-73-2 carboxylic acid methyl ester 
• 82185-43-1 N-(trimethylsilyl)-o-toluidine 
• 100414-86-6 [(1R,2R)-2-(1H-Indol-2-yl)-2-methyl-cyclohexyl]-methanol 
• 32885-53-3 hexahydrobenzofuranone 

Relevant articles and documents

ORGANOMETALLIC REAGENTS IN SYNTHESIS A NEW PROTOCOL FOR CONSTRUCTION OF THE INDOLE NUCLEUS

Organodilithium reagents derived from 2-alkyl-N-trimethylsilyl anilines undergo condensation with esters of carboxylic acids to afford substituted indoles.A total of 16 examples are reported; yields in general were good.In conjuction with this program, a convenient, large-scale procedure for preparation of monosilylated anilines was also developed.To demonstrate the utility of the new indole protocol in natural products synthesis, efficient syntheses of (+)-cinchonamine and (+)-epi-cinchonamine as well as a tetracyclic model system for the architecturally complex penitrem mycotoxins were completed in regio- and stereoselective fashion.