1094673-98-9Relevant academic research and scientific papers
Native chemical ligation at valine: A contribution to peptide and glycopeptide synthesis
Chen, Jin,Wan, Qian,Yuan, Yu,Zhu, Jianglong,Danishefsky, Samuel J.
, p. 8521 - 8524 (2008)
(Chemical Equation Presented) A Val-uable link: The title transformation is achieved by a two-step ligation, radicalbased desulfurization strategy (see scheme; NCL=native chemical ligation). After S→N acyl transfer, in which the acyl acceptor is a γ-thiol valine derivative, and site-specific dethiolation, a valine residue appears at the site of ligation. This method accomplishes ligations at Thr-Val and Pro-Val sites, and allows successful ligation of glycopeptide fragments.
