1094731-22-2Relevant academic research and scientific papers
Enantioselective total synthesis of 13-O-brefeldin A
Gao, Jian,Huang, Yi-Xian,Wu, Yikang
experimental part, p. 11105 - 11109 (2009/04/11)
An enantioselective route to the title compound, a heteroatom substituted close analogue of natural brefeldin A, is described. As a key step in the whole synthesis, concatenation of the lower chain and the cyclopentanone-upper chain moiety was achieved using a Rh-catalyzed Michael addition of a vinyl boronic acid to an enone, which effectively eliminated the problems encountered with the corresponding cuprate protocol and exemplified the potential of the strategy in synthesizing similar analogues.
