1094739-79-3Relevant academic research and scientific papers
Practical synthesis of novel purine analogues as Hsp90 inhibitors
Semeraro, Teresa,Mugnaini, Claudia,Manetti, Fabrizio,Pasquini, Serena,Corelli, Federico
experimental part, p. 11249 - 11255 (2009/04/06)
The development of a straightforward synthesis of 4-amino-6-benzyl-6H-pyrrolo[3,4-d]pyrimidine and 7-amino-2-benzyl-2H-pyrazolo[4,3-d]pyrimidine derivatives allowed for the preparation of a small family of potential Hsp90 inhibitors. Some of the newly synthesized compounds showed Hsp90 inhibitory activity in preliminary biological assays.
