1094754-90-1Relevant articles and documents
Five-membered heterocyclic oxo carboxylic acid compound and medical application thereof
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Paragraph 0952-0956, (2021/05/01)
The invention relates to a five-membered heterocyclic oxo carboxylic acid compound and a medical application thereof. Specifically, the invention relates to a compound, a pharmaceutical salt, a prodrug, a hydrate, a solvate or a crystal form as shown in a formula (I), and also relates to a preparation method of the compound, a pharmaceutical composition containing the compound and an application of the pharmaceutical composition as a secretion regulator of interferon type I, especially as an STING agonist in preparation of medicines for preventing and/or treating I-type interferon related diseases.
Suzuki-Miyaura cross-coupling reaction of naphthyl triflate with indole boronic acids catalyzed by a recyclable polymer-supported N-heterocyclic carbene-palladium complex catalyst: Synthesis of naphthalene-linked bis-heterocycles
Reddy, P. Aravinda,Reddy, A. Babul,Reddy, G. Ramachandra,Reddy, N. Subbarami
, p. 1451 - 1456 (2014/01/06)
In this study, the Suzuki-Miyaura cross-coupling reaction of naphthyl triflate with indole boronic acids catalyzed by a recyclable polymer-supported Pd-NHC complex catalyst is presented. The polymer-supported catalyst can be reused several times retaining high activity for the transformation. The structures of all the synthesized compounds were established by elemental analysis and from their mass, 1H-NMR, and 13C-NMR spectra.