109492-70-8

Basic information

• Product Name: (2S,4S)-1-acetyl-4-hydroxyproline ethyl ester
• Synonyms: (2S,4S)-1-acetyl-4-hydroxyproline ethyl ester
• CAS NO: 109492-70-8
• Molecular Weight: 201.222
• Mol File: 109492-70-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,4S)-1-acetyl-4-hydroxyproline ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4S)-1-acetyl-4-hydroxyproline ethyl ester(109492-70-8)
• EPA Substance Registry System: (2S,4S)-1-acetyl-4-hydroxyproline ethyl ester(109492-70-8)

Safety Data

• Hazardous Substances Data: 109492-70-8(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 72485-25-7 (1S,4S)-5-acetyl-2-oxa-5-azabicyclo<2.2.1>heptan-3-one 

Relevant articles and documents

Synthetic Applications of Electrochemically Produced α-Methoxyamides. Part 2) Oxidation of Hydroxyproline Derivatives

The electrochemical methoxylation of N-acetyl-4-hydroxyproline esters has been investigated.Both the free alcohol 3 and the corresponding 4-acetoxy derivative 4 as well as the cis-4-acetoxyproline 17 are methoxylated anodically preferentially at C(5), giving a mixture of stereoisomeric methoxy compounds.These mixtures can be used for further substitution as exemplified by the allylation of the methoxylated 4-acetoxy derivatives, giving substitution products preferentially trans to the acetoxy group although with low selectivity.The low selectivity is discussed in terms of kinetic vs. thermodynamic control.