1095024-77-3Relevant academic research and scientific papers
An easy and versatile synthesis of ureas from 2-benzylaminopyrimidine
Gool, Michiel Van,Bartolomé, José M.,Macdonald, Gregor J.
, p. 7171 - 7173 (2008)
A general procedure for the easy and versatile synthesis of ureas from 2-benzylaminopyrimidine is described. This methodology involves the preparation of a highly reactive carbamoyl chloride intermediate that can be further reacted with a high variety of different amines, including highly hindered secondary amines and deactivated anilines with excellent yields. Furthermore, this smooth procedure is compatible with a second functionality on the amine.
