1095074-07-9Relevant academic research and scientific papers
Synthesis of a new spiro-BOX ligand and its application in enantioselective allylic cyclization based on carbopalladation of allenyl hydrazines
Shu, Wei,Ma, Shengming
supporting information; experimental part, p. 6198 - 6200 (2010/02/16)
In this paper, we developed a new bisoxazoline ligand with a spiro skeleton and a α-naphthylmethyl substituent, i.e. (Ra,S,S)-L3, which has been successfully applied to the highly enantioselective cyclic allylation based on the carbopalladation
Studies on palladium-catalyzed enantioselective cyclization of 3,4-allenylic hydrazines with organic halides
Shu, Wei,Yang, Qing,Jia, Guochen,Ma, Shengming
experimental part, p. 11159 - 11166 (2009/04/11)
A convenient route to optically active pyrazolidine derivatives from Pd(0)/(R,R)-Bn-BOX-catalyzed enantioselective cyclization of 3,4-allenylic hydrazines in the presence of organic halides has been developed, the ee value is 75-84%. The absolute configuration of the products was determined by the conversion of one of the products to a known product prepared in this group. The reaction may proceed via the oxidative addition, intermolecular carbometallation of the allene moiety forming a π-allylic palladium intermediate, and the intramolecular enantioselective allylation.
