109508-84-1Relevant academic research and scientific papers
Regioselective C-H Amidation of (Alkyl)arenes by Iron(II) Catalysis
Ding, Yao,Zhang, Shen-Yuan,Chen, Yu-Chen,Fan, Shuai-Xin,Tian, Jie-Sheng,Loh, Teck-Peng
, p. 2736 - 2739 (2019)
A nondirected amidation reaction of aromatic C-H bond was developed under iron(II) catalysis, using sulfonyl azides as the nitrogen source. The reaction displayed a broad substrate scope and good regioselectivities in the aspects of aromatic ring vs alkyl
Optimized Synthetic Route for Enantioselective Preparation of (S)-Metolachlor from Commercially Available (R)-Propylene Oxide
Yang, Peng,Wang, Xiao,Peng, Lin,Chen, Feng,Tian, Fang,Tang, Chao-Zhe,Wang, Li-Xin
, p. 1682 - 1688 (2017)
An enantioselective preparation of (S)-metolachlor has been accomplished. The synthetic route featured the asymmetric preparation of chiral intermediates and the final (S)-metolachlor from commercially available (R)-propylene oxide and a key Fukuyama's process. The key steps, control points, separation purifications, and the whole process are optimized, and the target compound has been successfully prepared in five steps in 51-55% overall yield with excellent enantioselectivity (99% ee) up to a 30 g scale. By judicious choice of synthetic route and selection of starting materials and intermediates, no column chromatographic methods are needed for the separation and purification of the intermediates and the final products. The same strategy was extended as a general method for a series of pesticides and herbicide analogs of Metalaxyl-M and Dimethenamid-P.
