1095128-64-5

Upstream product

• 914220-97-6 2-(2-cyclopropylethynyl)benzaldehyde 
• 6746-94-7 Cyclopropylacetylene 
• 6630-33-7 ortho-bromobenzaldehyde 

Downstream Products

• 1314869-81-2 3-cyclopropyl-N-(4-isopropylphenyl)isoquinolin-1-amine 
• 1314869-74-3 N-cyclohexyl-3-cyclopropylisoquinolin-1-amine 
• 1314869-84-5 3-cyclopropyl-N-(4-nitrophenyl)isoquinolin-1-amine 
• 1314869-80-1 3-cyclopropyl-N-phenylisoquinolin-1-amine 
• 1314869-83-4 4-(3-cyclopropylisoquinolin-1-ylamino)benzonitrile 
• 1344731-22-1 3-cyclopropyl-1-phenoxyisoquinoline 
• 1344731-23-2 3-cyclopropyl-1-(2,6-dimethylphenoxy)isoquinoline 
• 1344731-24-3 3-cyclopropyl-1-(4-methoxyphenoxy)isoquinoline 
• 1344731-25-4 1-(4-tert-butylphenoxy)-3-cyclopropylisoquinoline 
• 1344731-26-5 1-(4-chlorophenoxy)-3-cyclopropylisoquinoline 
• 1344731-27-6 ethyl 4-(3-cyclopropylisoquinolin-1-yloxy)benzoate 
• 1401453-14-2 3-cyclopropyl-1-(4-fluorophenyl)isoquinoline 2-oxide 
• 1401453-15-3 3-cyclopropyl-1-(3-nitrophenyl)isoquinoline 2-oxide 
• 1589566-19-7 (Z)-1-(1-(3-benzylidene-1,3-dihydroisobenzofuran-1-yl)cyclopropyl)-3-cyclopropylisoquinoline 

Relevant academic research and scientific papers

Synthesis of N-(isoquinolin-1-yl)sulfonamides via Ag2O-catalyzed tandem reaction of ortho-alkynylbenzaldoximes with benchtop stabilized ketenimines

In this project, a moderately efficient approach to multisubstituted N-(isoquinolin-1-yl)sulfonamide derivatives was illustrated, utilizing ortho-alkynylbenzaldoximes and zwitterionic ketenimine salts in a tandem reaction catalyzed by silver oxide. The oxophilicity of Ag2O, along with its nature as Lewis acid, pave the way for a smooth [3 + 2] cycloaddition between isoquinoline N-oxides and ketenimine species, which is a key step in this reaction. DFT calculation suggests that 1,3-dipolar cycloaddition of nitrone and ketenimine proceeds through a selective stepwise mechanism.

Synthesis of 2-(Isoquinolin-1-yl)prop-2-en-1-ones via Silver(I)-Catalyzed One-Pot Tandem Reaction of ortho-Alkynylbenzaldoximes with Propargylic Alcohols

The silver(I)-catalyzed reaction of ortho-alkynylbenzaldoximes with propargylic alcohols represents a new strategy for the divergent one-pot synthesis of 2-(isoquinolin-1-yl) prop-2-en-1-ones via tandem 6-endo-cyclization, 1,3-dipolar cycloaddition, and intramolecular dehydrative opening of the 2,3-dihydroisoxazole ring. This synthetic protocol tolerates a wide variety of ortho-alkynylbenzaldoximes and propargylic alcohols and affords the corresponding products in excellent yields.

Efficient synthesis of isoquinoline derivatives via AgOTf/Cu(OTf) 2-cocatalyzed cyclization of 2-alkynyl benzaldoxime

An efficient, AgOTf and Cu(OTf)2 multicatalytic intramolecular cycloisomerization of 2-alkynylbenzaldoxime is reported. Isoquinoline N-oxides have been found to be deoxygenated to the corresponding quinolines in good yields in dimethylformamide/ dichloroethane (v/v 5:1) as solvent at 120 °C. Copyright Taylor & Francis Group, LLC.