1095273-18-9Relevant academic research and scientific papers
Enantioselective Cascade Michael-Michael Reactions and Related Catalysts
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Page/Page column 8, (2011/08/03)
The invention provides direct processes and related catalysts for the syntheses of trisubstituted chiral pyrrolidines, piperidines, tetrahydrothiophenes, and thianes by highly enantio- and diastereoselective cascade Michael-Michael reaction of α, β-unsatu
Highly enantio- and diastereoselective organocatalytic cascade aza-Michael-Michael reactions: A direct method for the synthesis of trisubstituted chiral pyrrolidines
Li, Hao,Zu, Liansuo,Xie, Hexin,Wang, Jian,Wang, Wei
supporting information; experimental part, p. 5636 - 5638 (2009/04/13)
An unprecedented highly enantio- and diastereoselective cascade aza-Michael-Michael reaction of α,β-unsaturated aldehydes with trans-γ-Ts protected amino α,β-unsaturated ester has been developed; the simple and practical process, efficiently catalyzed by chiral diphenylprolinol TMS ether, serves as a powerful access to highly functionalized trisubstituted chiral pyrrolidines. The Royal Society of Chemistry.
