1095320-85-6Relevant academic research and scientific papers
Studies towards the stereoselective α-hydroxylation of flavanones. Biosynthetic significance
Border, Zola-Michele,Marais, Charlene,Bezuidenhoudt, Barend C. B.,Steenkamp, Jacobus A.
, p. 122 - 130 (2008)
The enolates of various propiophenones, chromanones, and also analogues of naturally occurring flavanones were stereoselectively hydroxylated at the ?-position, by employing commercially available enantiopure oxaziridines, to afford the desired ?-hydroxylated target molecules in good to exceptional stereoselectivities and in moderate to good chemical yields. A mechanistic rationale is presented to account for the stereoselectivities achieved. These in vitro results were tentatively related to the stereoselective biosynthesis of enantio-enriched dihydroflavonols while questions were raised about the authenticity of certain natural compounds. CSIRO 2008.
