109552-66-1Relevant academic research and scientific papers
Simple Synthesis of Indoles and of Corresponding 3(2H)-Indolone Derivatives, Monosubstituted at the Benzene Ring, as Synthetic Precursors of Natural Compounds
Nimtz, Manfred,Haefelinger, Guenter
, p. 765 - 770 (2007/10/02)
Application of a specific BCl3-catalyzed ortho-chloroacetylation of the monosubstituted primary anilines 2a-e with chloroacetonitrile, as a variant of the Houben-Hoesch reaction, leads to the corresponding 2-amino-α-chloroacetophenones 3a-g.These may be reduced and cyclized to yield the indoles 4a-g or, after acylation to 5a-g and 7a, b converted by base-catalyzed dehydrochlorination into the 1-acyl-3(2H)-indolones 6a-g and 8a, b.
