1095536-63-2Relevant academic research and scientific papers
A diastereoselective route to 2,6-syn-disubstituted tetrahydropyrans: Synthesis of the civet compound (+)-2-((2S,6S)-6-methyltetrahydro-2H-pyran-2-yl) acetic acid
O'Brien, Matthew,Cahill, Shane,Evans, Lyndsay A.
scheme or table, p. 5559 - 5561 (2009/04/13)
A diastereoselective synthesis of 2,6-syn-disubstituted tetrahydropyrans has been developed based on the ability of furanyl-ether chiral centres to epimerise readily under acidic conditions. This novel methodology was applied to the synthesis of (+)-2-((2S,6S)-6-methyltetrahydro-2H-pyran-2-yl) acetic acid, a component of the African civet cat's glandular marking secretion. The Royal Society of Chemistry.
