1095559-91-3Relevant academic research and scientific papers
Synthesis, resolution, and application of cyclobutyl- and adamantyl-quinazolinap ligands
Fekner, Tomasz,Mueller-Bunz, Helge,Guiry, Patrick J.
, p. 5055 - 5066 (2008)
An expedient, seven-step synthesis of two new members of the Quinazolinap ligand family, 2-cyclobutyl- and 2-(1-adamantyl)-Quinazolinaps, has been developed. The racemic ligands have been efficiently resolved by fractional crystallization of their diastereomeric palladacycle complexes. The enantioenriched ligands provide good levels of enantioselection (ee's up to 89%) in a prototypical PdII-catalyzed allylic alkylation reaction. 2-Cyclobutyl-Quinazolinap has been further functionalized at the 2-position via metalation with a superbase followed by reaction with a range of electrophiles. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
